6-Gingerol Inhibits Hair Cycle via Induction of MMP2 and MMP9 Expression

    January 2017
    CHUN HOU, Yong Miao, Hang Ji, SUSHENG WANG, Gang Liang, Zhihua Zhang, Wei‐Jin Hong
    TLDR 6-Gingerol can slow down hair growth by affecting certain proteins.
    The study investigated the effects of 6-Gingerol, a major component of ginger, on hair growth in mice. Mice were divided into groups and treated with saline or varying concentrations of 6-Gingerol after hair removal. The findings revealed that 6-Gingerol, particularly at a concentration of 1 mg/mL, significantly inhibited hair growth by reducing hair re-growth ratio, hair follicle number, and hair follicle length. This suppression was linked to increased expression of MMP2 and MMP9. Additionally, 6-Gingerol decreased the concentrations of growth factors EGF, KGF, VEGF, and IGF-1, while increasing TGF-β concentration, suggesting its potential role as a hair growth suppressive agent by interfering with the hair cycle.
    Discuss this study in the Community →

    Related Community Posts Join

    6 / 1000+ results

      community 6 Month Finasteride only Results

      in Progress Pictures  133 upvotes 3 days ago
      A user shared their 6-month progress using finasteride for hair loss, reporting significant improvement without side effects. They previously used saw palmetto and currently take omega-3, curcumin, and vitamin D supplements.

      community 6 Months (July-December). Fin + Min.

      in Progress Pictures  373 upvotes 1 week ago
      The user experienced significant hair regrowth in six months using 1.25mg oral finasteride and topical Kirkland minoxidil once a day. Others suggested additional treatments like dermastamping and alternative products, while some noted varying responses and potential side effects.

      community 6 months journey. Minoxidil, fin, ketaconazole and dermaroller

      in Progress Pictures  30 upvotes 3 weeks ago
      A user shared their 6-month hair loss treatment journey using minoxidil, finasteride, ketoconazole, and a dermaroller, noting minimal changes between months 3 and 6. Other users discussed similar routines, cutting finasteride pills, and the benefits of using a dermastamp over a roller.

    Similar Research

    5 / 1000+ results