6-Gingerol Inhibits Hair Cycle via Induction of MMP2 and MMP9 Expression

    January 2017
    CHUN HOU, Yong Miao, Hang Ji, SUSHENG WANG, Gang Liang, Zhihua Zhang, Wei‐Jin Hong
    TLDR 6-Gingerol can slow down hair growth by affecting certain proteins.
    The study investigated the effects of 6-Gingerol, a major component of ginger, on hair growth in mice. Mice were divided into groups and treated with saline or varying concentrations of 6-Gingerol after hair removal. The findings revealed that 6-Gingerol, particularly at a concentration of 1 mg/mL, significantly inhibited hair growth by reducing hair re-growth ratio, hair follicle number, and hair follicle length. This suppression was linked to increased expression of MMP2 and MMP9. Additionally, 6-Gingerol decreased the concentrations of growth factors EGF, KGF, VEGF, and IGF-1, while increasing TGF-β concentration, suggesting its potential role as a hair growth suppressive agent by interfering with the hair cycle.
    Discuss this study in the Community →

    Related Community Posts Join

    6 / 1000+ results

      community 6 months of dutasteride + minoxidil.

      in Update  112 upvotes 3 days ago
      A 31-year-old male experienced significant hair regrowth after 6 months using daily 0.5 mg dutasteride, 5% topical minoxidil twice a day, occasional dermarolling, and hair supplements. He reported a slight decrease in libido initially but no other side effects, and there's potential for further improvement up to 12–18 months.

      community 6 months rogaine minoxidil update

      in Progress Pictures  6 upvotes 1 week ago
      The user has been using Rogaine (minoxidil), dermastamping, Nizoral shampoo, and spironolactone for 6 months with minimal visible results. They are advised to consider finasteride and be cautious with microneedling frequency and depth.

      community 6 Month Progress on Oral Fin/ Min

      in Progress Pictures  19 upvotes 1 week ago
      A 22-year-old is experiencing hair thinning and is using oral finasteride and minoxidil chewables, along with microneedling and anti-dandruff shampoo, to manage it. Despite experiencing significant shedding, they remain hopeful for regrowth in the coming months.

      community 6 month min only results + dermarolling

      in Progress Pictures  27 upvotes 2 weeks ago
      A user shared their 6-month progress using 1ml of Kirkland minoxidil daily and weekly 1mm dermarolling, noting no side effects and minimal shedding. They plan to consider finasteride or dutasteride after midterms, attributing hair loss to genetics.

    Similar Research

    5 / 1000+ results