Selenoproteins Are Essential for Proper Keratinocyte Function and Skin Development

    August 2010 in “ PLoS ONE ”
    Aniruddha Sengupta, Ulrike Lichti, Bradley A. Carlson … Dolph L. Hatfield
    Studysummary In this mouse study, severe selenoprotein deficiency in epidermal cells was linked to skin abnormalities, disrupted hair follicle development, and progressive alopecia, highlighting the role of selenoproteins in skin and hair health.
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    Research cited in this study 3

    1. The Human Keratins: Biology And Pathology Histochemistry and Cell Biology · 2008
    2. Isolation and Short-Term Culture of Primary Keratinocytes, Hair Follicle Populations, and Dermal Cells from Newborn Mice and Keratinocytes from Adult Mice for In Vitro Analysis and Grafting to Immunodeficient Mice Nature Protocols · 2008
    3. A Guide to Assessing Damage Response Pathways of the Hair Follicle: Lessons From Cyclophosphamide-Induced Alopecia in Mice Journal of Investigative Dermatology · 2005