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    Expression of Foxi3 Is Regulated by Ectodysplasin in Skin Appendage Placodes

    February 2013 in “ Developmental dynamics ”
    Vera Shirokova, Maria Jussila, Marjo K. Hytönen … Marja L. Mikkola
    Studysummary This study found that Eda and activin A regulate Foxi3 expression, which may contribute to the development of hypohidrotic ectodermal dysplasia by affecting Foxi3 activity in ectodermal appendages like hair and teeth.
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    Research cited in this study 12

    1. Sostdc1 Defines the Size and Number of Skin Appendage Placodes Developmental biology · 2012
    2. Identification of Ectodysplasin Target Genes Reveals the Involvement of Chemokines in Hair Development ˜The œjournal of investigative dermatology/Journal of investigative dermatology · 2012
    3. Conditional Activin Receptor Type 1B (Acvr1b) Knockout Mice Reveal Hair Loss Abnormality ˜The œjournal of investigative dermatology/Journal of investigative dermatology · 2010
    4. The Hair Follicle as a Dynamic Mini-Organ Current Biology · 2009
    5. TNF Superfamily in Skin Appendage Development Cytokine & growth factor reviews · 2008
    6. Identification of Dkk4 as a Target of Eda-A1/Edar Pathway Reveals an Unexpected Role of Ectodysplasin as Inhibitor of Wnt Signaling in Ectodermal Placodes Developmental biology · 2008
    7. Significant Correction of Disease After Postnatal Administration of Recombinant Ectodysplasin A in Canine X-Linked Ectodermal Dysplasia American Journal of Human Genetics · 2007
    8. Genetic Basis of Skin Appendage Development Seminars in cell & developmental biology · 2007
    9. Canonical WNT Signaling Promotes Mammary Placode Development and Is Essential for Initiation of Mammary Gland Morphogenesis Development · 2004
    10. Identification of a Secreted BMP Antagonist, Ectodin, Integrating BMP, FGF, and SHH Signals from the Tooth Enamel Knot Developmental biology · 2003
    11. Stimulation of Ectodermal Organ Development by Ectodysplasin-A1 Developmental Biology · 2003
    12. Edar/Eda Interactions Regulate Enamel Knot Formation in Tooth Morphogenesis Development · 2000

    Related research 1

    1. Advances in the Genetic Understanding of Hypohidrotic Ectodermal Dysplasia Expert opinion on orphan drugs · 2017