Sexual Dimorphism of Growth Plate Prehypertrophic and Hypertrophic Chondrocytes in Response to Testosterone Requires Metabolism to Dihydrotestosterone by Steroid 5-Alpha Reductase Type 1

    February 2005 in “ Journal of Cellular Biochemistry ”
    Perry Raz, E. Nasatzky, Barbara D. Boyan … Z. Schwartz
    Studysummary This study found that rat male costochondral chondrocytes, unlike female chondrocytes, respond to testosterone through metabolism to dihydrotestosterone, which shows a maturation-state dependent effect in male growth plate cells.
    Automatically generated from the study's abstract, not written by a person, and not a review of the full paper. Not medical advice or a treatment recommendation. Read the original study, and consult a qualified healthcare professional before changing treatment. Full disclaimer
    Read the full study on doi.org →
    Discuss this study in the Community →

    Research cited in this study 6

    1. Selective Non-Steroidal Inhibitors of 5α-Reductase Type 1 Journal of steroid biochemistry and molecular biology/˜The œJournal of steroid biochemistry and molecular biology · 2004
    2. 5 Alpha-Reductase Inhibitors: What's New? Current opinion in urology · 2003
    3. Human Osteoblast-Like Cells Express Predominantly Steroid 5α-Reductase Type 1 The Journal of Clinical Endocrinology & Metabolism · 2002
    4. The 5 Alpha-Reductase System and Its Inhibitors Dermatology · 1996
    5. Finasteride Drugs · 1993
    6. Regulation of Androgen Receptor and 5α-Reductase in the Skin of Normal and Hirsute Women Clinics in endocrinology and metabolism · 1986

    Related research 4

    1. Evaluation of the Therapeutic Effects of AGA Drugs by Measuring Finasteride, Dutasteride, and Dihydrotestosterone in Hair Clinica Chimica Acta · 2023
    2. The Effects of Finasteride on Scalp Skin and Serum Androgen Levels in Men with Androgenetic Alopecia Journal of The American Academy of Dermatology · 1999
    3. The Effect of Finasteride, a 5 Alpha-Reductase Inhibitor, on Scalp Skin Testosterone and Dihydrotestosterone Concentrations in Patients with Male Pattern Baldness The Journal of Clinical Endocrinology and Metabolism · 1994
    4. Comparison of Finasteride, a 5α Reductase Inhibitor, and Various Commercial Plant Extracts in In Vitro and In Vivo 5α Reductase Inhibition The Prostate · 1993