Netherton Syndrome: Effect on Ichthyosis Linearis Circumflexa with Dupilumab

    October 2025 in “ Journal of Dermatological Treatment ”
    Ashleigh Ka Ying Chu, James W. C. H. Cheng, Ying Yin Lam … David Luk
    Studysummary This case study reported that Dupilumab treatment improved eczema, itch, and hair condition in a girl with Netherton Syndrome, as shown by over 40% improvement in various dermatological scores; however, significant flares of ichthyosis linearis circumflexa persisted.
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    Research cited in this study 3

    1. Severe Hypernatremia as Presentation of Netherton Syndrome Global Medical Genetics · 2023
    2. Netherton Syndrome Subtypes Share IL-17/IL-36 Signature With Distinct IFN-α and Allergic Responses Journal of Allergy and Clinical Immunology · 2021
    3. A Unique Case of Trichorrhexis Nodosa: Bamboo Hairs Archives of Dermatology · 1958