Cyclosporin A Promotes Hair Epithelial Cell Proliferation and Modulates Protein Kinase C Expression and Translocation in Hair Epithelial Cells

September 2001 in “ Journal of Investigative Dermatology ”

Tomoya Takahashi, Ayako Kamimura

Cyclosporin A hair epithelial cells epidermal keratinocytes protein kinase C PKC isozymes α isozyme βI isozyme βII isozyme η isozyme CsA PKC

Studysummary This study found that cyclosporin A stimulates growth in cultured murine hair epithelial cells and reduces protein kinase C expression, suggesting that these actions may contribute to its hair-growing effects.

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research Several Selective Protein Kinase C Inhibitors Including Procyanidins Promote Hair Growth

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In this study, procyanidin B-2 and C-1 were found to promote hair growth by selectively inhibiting protein kinase C, supporting their potential use for hair-growing activity.

research Overexpression of Protein Kinase C-α in the Epidermis of Transgenic Mice Results in Striking Alterations in Phorbol Ester-Induced Inflammation and COX-2, MIP-2, and TNF-α Expression but Not Tumor Promotion

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This study found that overexpression of PKCα in mouse epidermis increases expression of specific proinflammatory mediators and induces inflammation but does not significantly affect epidermal differentiation, proliferation, or tumor promotion with TPA.

Procyanidin Oligomers Selectively and Intensively Promote Proliferation of Mouse Hair Epithelial Cells In Vitro and Activate Hair Follicle Growth In Vivo

research Procyanidin Oligomers Selectively and Intensively Promote Proliferation of Mouse Hair Epithelial Cells In Vitro and Activate Hair Follicle Growth In Vivo

79 citations , March 1999 in “The journal of investigative dermatology/Journal of investigative dermatology”

This study found that procyanidin oligomers, particularly dimers and trimers, significantly promoted hair growth in mice and hair epithelial cell cultures, suggesting potential use as hair growth agents.

research Interleukin-1β Is Differentially Expressed by Human Dermal Papilla Cells in Response to PKC Activation and Is a Potent Inhibitor of Human Hair Follicle Growth in Organ Culture

38 citations , March 1997 in “Journal of interferon & cytokine research”

This study suggests that IL-1β produced by dermal papilla cells, regulated by protein kinase C, may inhibit human hair follicle growth through paracrine signaling.

research Bisindolylmaleimide Protein Kinase C Inhibitors Delay the Decline in DNA Synthesis in Mouse Hair Follicle Organ Cultures

11 citations , January 1997 in “Skin Pharmacology and Physiology”

This study found that bisindolylmaleimide PKC inhibitors increased DNA synthesis in mouse hair follicles, suggesting that PKC may inhibit hair follicle proliferation.

research Formation and Structure of Human Hair

175 citations , January 1995 in “Birkhäuser Basel eBooks”

This review examines the histochemistry and keratinization processes of human hair, exploring the structural roles of keratin proteins, protein chains, and lipids, but offers no new results.

research Effects of Immunosuppressive Peptidyl-Prolyl Cis-Trans Isomerase (PPIase) Inhibitors, Cyclosporin A, FK506, Ascomycin, and Rapamycin, on Hair Growth Initiation in Mice: Immunosuppression Is Not Required for New Hair Growth

20 citations , January 1995 in “Journal of Dermatological Science”

This study found that topical application of cyclosporin A and FK506 induces new hair growth in mice, while ascomycin and rapamycin do not, suggesting hair induction is not due to immunosuppression.

research Hair Growth on Nude Mice Due to Cyclosporin A

25 citations , December 1991 in “The Journal of Dermatology”

This study found that cyclosporin A treatment in young nude mice induced dose-dependent hair growth, which stopped after treatment cessation, but did not result in hair growth in older mice.

research Topical Cyclosporine in Male Pattern Alopecia

33 citations , February 1990 in “Journal of the American Academy of Dermatology”

Topical cyclosporine led to significant hair growth in some men with male pattern baldness.

research Differences in Activity of Minoxidil and Cyclosporin A on Hair Growth in Nude and Normal Mice: Comparisons of In Vivo and In Vitro Studies

35 citations , January 1990 in “PubMed”

This study found that oral cyclosporin A increased hair growth in nude mice, while minoxidil did not have the same effect.

research Cyclosporin A Stimulates Hair Growth in Nude Mice

55 citations , June 1987 in “PubMed”

In this study, cyclosporin A treatment significantly increased hair length in nude mice compared to controls, but hair growth reversed after treatment stopped.