CCN2 Modulates Hair Follicle Cycling in Mice

    October 2013 in “ Molecular Biology of the Cell ”
    Shangxi Liu, Andrew Leask
    Studysummary This study found that the protein CCN2 in dermal papilla cells is a physiologically relevant suppressor of hair follicle formation by destabilizing β-catenin, which may help maintain stem cell quiescence.
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    Research cited in this study 8

    1. Tuning Wnt Signals for More or Fewer Hairs Journal of Investigative Dermatology · 2013
    2. Coordinated Activation of Wnt in Epithelial and Melanocyte Stem Cells Initiates Pigmented Hair Regeneration Cell · 2011
    3. Hedgehog Signaling Maintains Hair Follicle Stem Cell Phenotype in Young and Aged Human Skin Aging Cell · 2009
    4. The Mesenchymal Component of Hair Follicle Neogenesis: Background, Methods, and Molecular Characterization Experimental Dermatology · 2009
    5. Wnt-Dependent De Novo Hair Follicle Regeneration in Adult Mouse Skin After Wounding Nature · 2007
    6. Transient Activation of Beta-Catenin Signaling in Adult Mouse Epidermis Induces New Hair Follicles, Continuous Activation Maintains Tumors Development · 2004
    7. Keratin 15 Promoter Targets Putative Epithelial Stem Cells in the Hair Follicle Bulge Journal of Investigative Dermatology · 2003
    8. Molecular Mechanisms Regulating Hair Follicle Development ˜The œjournal of investigative dermatology/Journal of investigative dermatology · 2002

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    2. Canonical Wnt-10b Signaling Exerts an Ability to Maintain Mouse Dermal Papilla Cells Journal of Dermatological Science · 2016
    3. Activation of Beta-Catenin Signaling in CD133-Positive Dermal Papilla Cells Drives Postnatal Hair Growth PLOS ONE · 2016
    4. Beta-Catenin Activity in the Dermal Papilla Regulates Morphogenesis and Regeneration of Hair Developmental Cell · 2010
    5. Hair Follicle Expression of 1,25-Dihydroxyvitamin D3 Receptors During the Murine Hair Cycle British Journal of Dermatology · 2006