In this study, water-solubleminoxidil promoted hair growth and influenced the hair cycle in a C57BL/6 mouse alopecia model, particularly at a 1.5% concentration.
6 citations
,
March 2018 in “Journal of Medicinal Food”
This study demonstrated that water-soluble peptides from egg yolk, termed "hair growth peptide," stimulated human hair follicle cell growth and improved hair growth in female pattern hair loss.
April 2018 in “Journal of Investigative Dermatology”
This study found that a water-soluble peptide from chicken egg yolk, named Hair Growth Peptide, improved hair growth in mice and female pattern hair loss through increased IGF-1 and VEGF production.
This study reported that chemically modified cellulose from pineapple waste effectively created nanoparticles for minoxidil delivery with high encapsulation efficiency and prolonged release, potentially useful for androgenic alopecia treatment.
March 2023 in “ACS Applied Materials & Interfaces”
This study reports that a water-soluble microneedle patch with minoxidil-loaded microspheres showed similar or better hair regeneration effects in mice with less frequent application compared to daily topical minoxidil.
RU-58841 does not dissolve well in common Minoxidil solutions due to water content, requiring a 70/30 ethanol/propylene glycol mix. Users report using separate solutions for RU-58841 and finasteride/Minoxidil for better results.
A user experienced significant hair regrowth using topical minoxidil, water-soluble pumpkin seed oil, and saw palmetto. Despite not using finasteride, the user reported reduced hair loss and increased hair growth, especially around the temples and beard.
The conversation discusses adding crushed finasteride tablets to topical minoxidil, but it's advised against because the tablets are not water-soluble and meant for oral use. The suggestion is to take finasteride orally instead.
RU58841 is more effective when mixed with isopropyl alcohol instead of minoxidil, as water in minoxidil degrades RU58841. Applying RU58841 separately from minoxidil, with an hour gap, enhances hair growth results.
Minoxidil with alcohol and propylene glycol was more effective than non-alcohol versions, and RU58841 worked best in a non-water-based solution. Oral finasteride showed better results than topical, despite side effects; microneedling and tretinoin worsened hair loss, and PRP was only helpful when younger.
Vasodilator used on the scalp and, at low doses, as a tablet
From hypertension to hair: the unexpected story of minoxidilMinoxidil was developed as an oral blood-pressure drug and approved as Loniten in 1979; unwanted hair growth in patients led to topical Rogaine, approved for men in 1988 and for women in 1991. Trials support topical minoxidil for pattern hair loss, while low-dose oral minoxidil is a prescription drug used off-label and needs medical supervision.
Minoxidil 2%, 5% and 10% which is better to use?In a randomized trial in men, 5% topical minoxidil produced more hair growth than 2%, and in one small trial 10% did not beat 5% and caused more irritation. No 10% product is approved in the US, and approved strengths differ by sex, so check the label for your product.
Vitamins vs. minoxidil: who wins the battle for hair growth?Topical minoxidil is approved for pattern hair loss and has trial evidence; reviews find that reported benefits of vitamins such as biotin come mainly from people with a deficiency. The FDA warns that biotin supplements can make some blood tests give wrong results.