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research Valproic acid. A reappraisal of its pharmacological properties and clinical efficacy in epilepsy.

294 citations , February 1994 in “PubMed”

This review highlights valproic acid's efficacy and tolerability as a first-line treatment for various seizure types in both adults and children, emphasizing its minimal neurological adverse effects compared to other antiepileptic drugs.

research Valproate in the Treatment of Persistent Chronic Daily Headache. An Open Label Study

111 citations , February 1991 in “Headache The Journal of Head and Face Pain”

In this study, two-thirds of patients with persistent chronic daily headache significantly improved with divalproex sodium treatment, while liver functions remained unaffected.

research Validation and Reference Ranges of Hair Cortisol Measurement in Healthy Children

85 citations , January 2014 in “Hormone Research in Paediatrics”

This study found that hair cortisol concentrations can be reliably measured in healthy children and generally increase with age, unaffected by gender, puberty, or hair care practices.

research Valproic Acid Induces Hair Regeneration in Murine Model and Activates Alkaline Phosphatase Activity in Human Dermal Papilla Cells

85 citations , April 2012 in “PLOS ONE”

This study found that valproic acid promoted hair re-growth in C3H mice by activating the Wnt/β-catenin pathway, suggesting its potential as a treatment for alopecia.

research Low Serum Biotinidase Activity in Children with Valproic Acid Monotherapy

73 citations , October 2001 in “Epilepsia”

In this study, valproic acid treatment was associated with reduced biotinidase activity and improved skin lesions after biotin supplementation in children with seizures.

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learn Valproic acid

an anticonvulsant repurposed for hair loss via histone inhibition

What is valproic acid, and how did it become a subject of interest in hair growth and alopecia research? Valproic acid is a prescription anticonvulsant that laboratory and mouse studies link to the Wnt/β-catenin hair-growth pathway; one small randomized trial of an 8.3% topical spray reported a hair-count gain over 24 weeks. Oral valproate is also a recognized cause of hair loss and a known teratogen.
How is valproic acid being explored differently in topical hair products compared to its traditional oral medical use? Topical valproic acid is being studied for local effects on the hair follicle rather than the whole-body effects of the oral drug. The human evidence is one small randomized 24-week trial of an 8.3% spray; no topical valproate product is approved for hair loss.
What biological mechanisms related to hair follicles are linked to valproic acid in experimental treatments? Valproic acid affects hair follicles by modulating cell signaling and gene regulation.
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community Any validity to this product being sold by a social media influencer?

in Product 1 year ago

The conversation is about skepticism towards a hair growth oil promoted by a social media influencer, with users suggesting it is ineffective without proven treatments like Minoxidil, finasteride, or hair transplants. The product contains various oils and extracts, but users doubt its effectiveness.

community Can valisone solution cause hairloss?

1 upvotes 7 years ago

A user is concerned that prolonged use of valisone (betamethasone) and clotrimazole solution for scalp dermatitis may be causing hair thinning and loss. They noticed thinning in the area where the solution was applied.

community Source for topical valproic acid?

2 upvotes 8 months ago

The conversation is about finding a source for topical valproic acid for hair regrowth. The user mentions PP405 and the unavailability of products from certain suppliers.

community Important blood values on Dut?

7 upvotes 9 months ago

The conversation is about a user planning a blood test to monitor health while on hair loss treatments: Finasteride, Minoxidil, and Dutasteride. Recommendations include testing for androgens, thyroid function, micronutrients, and basic health markers, with additional suggestions for PSA, prolactin, and estradiol.

community Better Than Minoxidil? Topical Sodium Valproate

50 upvotes 1 year ago

Topical sodium valproate may promote hair growth by inhibiting GSK3β, allowing beta-catenin to proliferate, but it has potential side effects and requires more research. The conversation also mentions skepticism about a product called Vdphlo1, which includes sodium valproate and other ingredients.

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