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research Multi-Omics Reveals That Hydroxypinacolone Retinoate Alleviates UV-Induced Skin Aging via the p38/MMP9/Collagen Axis

August 2026 in “Clinical Cosmetic and Investigational Dermatology”

This study found that Hydroxypinacolone Retinoate (HPR) may alleviate UV-induced skin photoaging by enhancing collagen synthesis, reducing degradation, and modulating inflammatory and oxidative responses in a dose-dependent manner.

research Fruit Acid Inhibits UV-Induced Skin Aging via PI3K/Akt and NF-κB Pathway Inhibition

3 citations , January 2025 in “Discovery Medicine”

This study found that glycolic acid treatment reduced oxidative stress and inflammation in UV-induced skin photoaging in rats, promoting collagen recovery and reducing photoaging signs, potentially by inhibiting the PI3K/Akt and NF-κB pathways.

research Editorial: Inflammation, stem cells and wound healing in skin aging

October 2022 in “Frontiers in Cell and Developmental Biology”

Aging skin is affected by inflammation, reduced stem cell function, and slower wound healing.

research Effect of conditioned media collected from human amniotic fluid-derived stem cells (hAFSCs) on skin regeneration and photo-aging

9 citations , February 2014 in “Tissue Engineering and Regenerative Medicine”

This study found that conditioned media from human amniotic fluid-derived stem cells may enhance skin regeneration by promoting cell proliferation and migration, and by modulating gene expressions altered by UV irradiation.

research Non-denatured Soybean Extracts in Skin Care: Multiple Anti-Aging Effects

2 citations , April 2011 in “InTech eBooks”

This review discusses the potential skin care benefits of non-denatured soybean extracts, including skin lightening and UV protection, but reports no clinical results.

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Community Join

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community So does oral minoxidil age your skin or not

43 upvotes 2 years ago

Oral minoxidil may cause dry skin and dark eye bags but doesn't significantly age the skin. Topical minoxidil is toxic to cats, and some users prefer finasteride.

community Minoxidil actually reduces wrinkles

in Research/Science 209 upvotes 1 year ago

Minoxidil may improve or worsen skin quality, with topical forms causing dryness and wrinkles, possibly due to alcohol content, while oral forms have fewer side effects. Some users consider using tretinoin to mitigate negative effects.

community Best Supplements (If Any) That Will Help Speed Things Up and Enhance Results

2 upvotes 4 years ago

The conversation discusses using topical minoxidil and finasteride, along with dermarolling and biotin shampoo, for hair loss treatment. It also explores supplements like NutraPro's hair growth formula and other products like tretinoin, Ducray shampoo, and Nizoral to enhance results.

community Peptides that Stop Hair Loss? | In-depth Literature Review Video

76 upvotes 2 years ago

Peptides like TB500, KPV, GHK-CU, and BPC-157 are overhyped for hair growth with limited proven effectiveness in humans. Combining peptides with delivery methods like iontophoresis and sonophoresis shows promise, but many claims remain unproven.

community The Real Cause Of Androgenetic Alopecia

675 upvotes 1 year ago

Androgenetic alopecia is caused by DHT affecting hair growth. Finasteride and minoxidil are used to manage hair loss by blocking DHT and promoting hair growth.

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Learn

1 / 800 results

learn Melatonin

hormone commonly taken for sleep aid has some topical benefits for hair

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Clinics

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All 68 clinic results →

Experts

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SMP Specialist
Noelle Skin
Nice, France

Noelle Skin