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learn Dutasteride

Heavy duty finasteride that comes with higher risks

Dutasteride: Correct Dosage and Administration The standard dosage of dutasteride is 0.5 mg once daily.
Dutasteride side effects: what the label and studies actually report The Avodart label reports impotence in 4.7% and decreased libido in 3.0% of men in the first six months (1.7% and 1.4% on placebo), with new reports falling after month six; those figures come from BPH trials in older men, and the hair-loss trials in younger men run only six months. The label and studies also flag a PSA drop of about half, a small rise in high-grade prostate cancer in one trial, an observational link to depression, and sexual effects that the label says may persist after stopping.
Will I notice changes in my body if I start taking dutasteride? Dutasteride lowers DHT, so labels and trials describe prostate shrinkage over 3-6 months and, off-label, slowed hair loss; the same sources list sexual side effects and an observational link to depression.
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learn Fluridil

a topical anti-androgen with less systemic involvement

learn Clascoterone

a novel topical treatment that inhibits DHT on androgen receptors

learn dehydroepiandrosterone

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Community Join

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community Ulo low dose dut/fin hair serum

4 upvotes 9 months ago

The user experienced severe sexual side effects from topical finasteride with minoxidil but found no side effects with low-dose dutasteride and finasteride serums from Ulo after a hair transplant. They also used a hair growth serum with saw palmetto without side effects.

community 52 year old norwood 6 vellus to terminal, 5 months progress

12 upvotes 2 months ago

A 52-year-old with Norwood 6 hair loss shows progress after 5 months using topical dutasteride, LLLT, copper peptides, Ulo serum, Minoxidil, cetirizine, and microneedling. Native hair is regrowing from vellus to terminal, with increased density in previously bald areas.

community Phase II topical dut study - outperforms oral fin with a minor DHT reduction

in Research/Science 61 upvotes 7 months ago

Topical dutasteride 0.05% is more effective for hair growth than oral finasteride 1mg, with minimal DHT reduction. The formulation uses castor oil and MCTs for better absorption but is not widely available until 2028.

community How much DHT causes hair loss ?

in Finasteride/Dutasteride 2 upvotes 10 months ago

The user is taking 2.5 mg dutasteride and 5% minoxidil but is not seeing hair regrowth, and is considering adding RU58841. They are experiencing fatigue and low MCV/MCH, possibly related to dutasteride, and are advised to be patient, consider microneedling, and check for iron deficiency.

community 25 years on Finasteride and it's not working anymore.

324 upvotes 6 months ago

A 47-year-old has been using finasteride for 25 years for hair loss, but it's less effective now. Suggestions include switching to dutasteride, stopping anastrozole, and trying minoxidil, microneedling, and possibly TRT.

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Research

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research Analytical methods of dutasteride: An overview

December 2023 in “Annals of phytomedicine”

This study reports that dutasteride, used alone or with tamsulosin, effectively reduces acute urine retention and surgery risk in men with benign prostatic hyperplasia, and may lower prostate cancer incidence, suggesting potential chemopreventive benefits.

research 198 Dutasteride for men with androgenic alopecia unresponsive to finasteride

August 2016 in “Journal of Investigative Dermatology”

This study found that among men unresponsive to finasteride for androgenic alopecia, 56.25% showed significant hair improvement after six months of dutasteride treatment with reasonable adverse effects.

research Marked Suppression of Dihydrotestosterone in Men with Benign Prostatic Hyperplasia by Dutasteride, a Dual 5α-Reductase Inhibitor

408 citations , May 2004 in “The Journal of clinical endocrinology and metabolism/Journal of clinical endocrinology & metabolism”

This study found that dutasteride more effectively reduced serum dihydrotestosterone levels than finasteride in patients with benign prostatic hyperplasia.

Dutasteride, A Novel Dual 5-Alpha Reductase Inhibitor, Reduces Serum DHT to a Greater Extent Versus Finasteride and Achieves Maximal Reduction in a Larger Proportion of Patients

research Dutasteride, a novel dual 5-A reductase inhibitor, reduces serum DHT to a greater extent versus finasteride and achieves finasteride maximal reduction in a larger proportion of patients

12 citations , February 2003 in “European Urology Supplements”

Dutasteride reduces DHT more effectively than finasteride.

research Prospective randomized study of sexual function in men taking dutasteride for the treatment of androgenetic alopecia

11 citations , April 2018 in “Journal of Dermatology”

In a randomized study, men treated with dutasteride for androgenetic alopecia experienced sexual adverse events at twice the rate of those on placebo during 24 weeks, but these events were mild, moderate, and resolved after treatment.

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66
Hair Transplant Surgeon
Dr. Raghu Sai Ram, MDS
Hyderabad, Telangana, India

Dr. Raghu Sai Ram, MDS