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research Type 1 interferon signature in the scalp lesions of alopecia areata

52 citations , March 2010 in “British Journal of Dermatology”

This study demonstrated the expression of type 1 interferon-related proteins in inflammatory lesions of alopecia areata, showing a distinct distribution pattern compared to cicatricial alopecia.

research Type 1 interferon signature and cytotoxic T lymphocyte activation targeted against sweat ducts in inflammatory acquired idiopathic generalized anhidrosis

6 citations , June 2023 in “Journal of the European Academy of Dermatology and Venereology”

This study observed that inflammatory AIGA is associated with sweat duct inflammation and sweat coil atrophy, while non-inflammatory AIGA involves only sweat coil atrophy, suggesting distinct pathological features between the two.

research The Role of Interferon-γ in Autoimmune Polyendocrine Syndrome Type 1

71 citations , May 2024 in “New England Journal of Medicine”

This study investigated the impact of the JAK inhibitor ruxolitinib on APS-1 patients, reporting that treatment decreased excessive T-cell-derived interferon-γ, normalized inflammatory markers, and led to remission of several autoimmune symptoms without serious adverse effects.

research 1326 Translation-dependent skin hyperplasia is promoted by type 1/17 inflammation in psoriasis

April 2023 in “Journal of Investigative Dermatology”

In this study, researchers found that the protein eIF4E is crucial for keratinocyte proliferation in psoriasis, suggesting it as a potential treatment target for the condition.

research Autoimmune Polyglandular Syndrome Type 1 in Russian Patients: Clinical Variants and Autoimmune Regulator Mutations

62 citations , January 2010 in “Hormone research in paediatrics”

This study found that the R257X mutation in the AIRE gene is prevalent among Russian patients with autoimmune polyglandular syndrome type 1, particularly in those with hypoparathyroidism and chronic mucocutaneous candidiasis.

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community 5 alpha reductase type 1 is in brain tissue producing the main endogenous gabaergic allopregnanolone, not 2. How can finasteride as a 5ar2 lower that?

27 upvotes 1 year ago

Finasteride and dutasteride are discussed for hair loss, with concerns about their effects on neurosteroids and potential side effects like depression. Alternatives like topical estrogen and lifestyle changes are considered, with varying opinions on mental health and hair regrowth.

community 10 month update - 4 in 1 topical solution + dermastamp (sorry for the low quality before)

306 upvotes 5 months ago

A user shared their positive experience with a 4-in-1 topical solution containing finasteride, minoxidil, ketoconazole, and biotin, along with weekly microneedling using a 1.2mm dermastamp. The user reported no noticeable side effects and mentioned that the biotin likely doesn't contribute to hair growth.

community New vellus all over — just 9 days into once-daily 5% minoxidil.

161 upvotes 8 months ago

The user has been using 1 mg finasteride for three months and recently started using 5% minoxidil once daily, resulting in new vellus hair growth. The user is hopeful that minoxidil will positively impact terminal hairs and is considering adding a derma stamp to the routine.

community Using ketoconazole shampoo daily?

in Ketoconazole 24 upvotes 7 months ago

Using ketoconazole shampoo daily can dry out hair, and most users recommend using it 1-2 times a week with conditioner. Some users combine it with minoxidil and finasteride for better hair growth results.

community My understanding of how androgenetic alopecia works (plus FIN and DUT)

18 upvotes 4 years ago

Androgenetic alopecia is affected by scalp DHT levels, not sensitivity, with treatments like finasteride and dutasteride aiming to optimize these levels. Personalized DHT management is crucial for effective hair growth.

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learn Stem Cell Factor

learn Osteopontin

signaling protein that, when suppressed, may grow hair by reducing inflammation and stem cell loss

learn Hair Transplant

Can a diabetic patient undergo a hair transplant? Diabetic patients can have hair transplants if their condition is well-controlled.
What results can I expect from a hair transplant? Expect new hair growth in 3-4 months, with full results in 9-12 months.
Who is a good candidate for a hair transplant? Good candidates for hair transplants have sufficient donor hair and stable hair loss patterns.
All 5 questions on Hair Transplant →

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