6 citations
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October 2022 in “Frontiers in Cell and Developmental Biology”
This study suggests that hairfollicle mesenchymal stem cells may alleviate small intestinal ischemia-reperfusion injury in rats by promoting angiogenesis, reducing apoptosis, and enhancing intestinal stem cell expression.
December 2023 in “International Journal of Medical Arts”
In this study, researchers observed significant morphological and histological differences in transplantedhairfollicles compared to native donor follicles post-FUE hair transplantation for androgenetic alopecia, highlighting substantial variations in sebaceous gland and root sheath degeneration at the recipient site.
This study suggests that hairfollicle mesenchymal stem cells may alleviate small intestinal ischaemia-reperfusion injury in rats by promoting angiogenesis, reducing apoptosis, and protecting intestinal mucosal function.
This study found that hairfollicle stem cells, when transplanted in a rat model of ischaemic stroke, migrated to affected areas, expressed neuron-specific markers, and reduced infarct volume, suggesting potential therapeutic benefits.
Hair/scalp cloning for unlimited transplants is likely a decade away, with prior transplants not significantly affecting future options. Advances in AI and research in wound-induced hair neogenesis are promising, but infrastructure and technology constraints remain challenges.
PP405 cannot restore extracted hairfollicles after a transplant as they are removed, not dormant. Combining verteporphin with wounding and PP405 is suggested but not confirmed effective.
Hairtransplants typically involve spreading follicle extraction across the back and sides of the head to maintain an even appearance, rather than taking a solid rectangle of grafts. FUT procedures, which involve taking a strip of skin, are less common now due to advancements in techniques like FUE, which heal well and are less invasive.
Topical Metformin shows potential for regenerating hairfollicles and minimizing scarring in hairtransplant donor areas, similar to Verteporfin but without its side effects. The discussion suggests considering Metformin for post-hairtransplant care, though more human trials are needed.
PP405 may reactivate dormant hairfollicles but won't replace hairtransplants or resurrect dead follicles. Its effectiveness, cost, and impact compared to treatments like minoxidil and finasteride are uncertain.
Hair transplantation moves DHT-resistant follicles from a donor area (back and sides of the scalp) into thinning or bald areas. The transplantedhair is generally permanent, though surrounding native hair can keep thinning.