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GlossaryPost-Transcriptional Gene Silencing

cells inhibit gene expression after RNA is made

Post-Transcriptional Gene Silencing (PTGS) is a cellular process where the expression of specific genes is inhibited after the DNA has been transcribed into RNA. This is often achieved through mechanisms like RNA interference (RNAi), where small RNA molecules bind to the messenger RNA (mRNA) and prevent it from being translated into proteins. This process is crucial for regulating gene expression and maintaining cellular function.

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research Investigation of Transcriptional Gene Profiling in Normal Murine Hair Follicular Substructures Using Next-Generation Sequencing to Provide Potential Insights into Skin Disease

1 citations , February 2016 in “Cell Transplantation”

Hair follicles have a more inactive cell cycle than other skin cells, which may help develop targeted therapies for skin diseases and cancer.

research MicroRNAs in the Skin: Role in Development, Homeostasis, and Regeneration

31 citations , July 2017 in “Clinical Science”

MicroRNAs are important for skin health and could be targets for new skin disorder treatments.

research ESGCT and FSGT Collaborative Congress Helsinki, Finland September 17–20, 2015 Abstracts

2 citations , October 2015 in “Human Gene Therapy”

The congress highlighted new gene therapy techniques and cell transplantation methods for treating diseases.

Development and Evaluation of Antisense shRNA-Encoding Plasmid Loaded Solid Lipid Nanoparticles Against 5-Alpha Reductase Activity

research Development and Evaluation of Antisense shRNA-Encoding Plasmid Loaded Solid Lipid Nanoparticles Against 5-Alpha Reductase Activity

12 citations , January 2018 in “Journal of Drug Delivery Science and Technology”

The new particle system could be a promising treatment for diseases related to the 5-α reductase enzyme.

research Control by a Hair’s Breadth: The Role of MicroRNAs in the Skin

41 citations , September 2012 in “Cellular and Molecular Life Sciences”

MicroRNAs play a crucial role in skin and hair health, affecting everything from growth to aging, and could potentially be used in treating skin diseases.

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community What happened to the ‘funding’ for broccoli research in treating hair loss?

in Chat 41 upvotes 3 years ago

Hair loss discussion includes broccoli sprouts treatment, Fluridil 7%, and sulforaphane, with mixed results. Finasteride, minoxidil, and RU58841 are preferred by some users.

community The Real Cause Of Androgenetic Alopecia

in Research/Science 673 upvotes 10 months ago

Androgenetic alopecia is caused by DHT affecting hair growth. Finasteride and minoxidil are used to manage hair loss by blocking DHT and promoting hair growth.

community HLT Megathread on HMI-115 (key takeaways in comments)

in Research/Science 39 upvotes 2 years ago

HMI-115, a newly discovered hair loss treatment that could potentially be effective for those with diffuse thinning and telogen effluvium. It is based on prolactin receptor antagonist signaling and has already undergone Phase I trials in women, with potential commercialization by 2027.

community Testosterone in Reference Range Doesn't Cause Hair Loss

in Research/Science 53 upvotes 1 year ago

Testosterone within the normal range does not significantly contribute to male pattern baldness (MPB); DHT is the main factor that can be controlled. Genetics play a crucial role in hair loss, and treatments like finasteride and dutasteride, which block DHT, can help despite potentially raising testosterone levels.

community Minoxidil Response Bottlenecks: Why Sulfation and Transport Matter (And Where Tretinoin Fits In)

in Research 461 upvotes 2 months ago

Minoxidil's effectiveness is limited by the need for sulfation and proper transport to hair follicles, with tretinoin potentially enhancing its effects by promoting enzyme activity and keratinocyte differentiation. Tretinoin may improve minoxidil's response by boosting the expression of necessary enzymes and transporters.

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