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research Enhancing Permeation of Drug Molecules Across the Skin via Delivery in Nanocarriers: Novel Strategies for Effective Transdermal Applications

365 citations , March 2021 in “Frontiers in Bioengineering and Biotechnology”

This review discusses the potential of nanocarriers to enhance transdermal drug delivery and the combination of these carriers with physical methods, but it reports no new experimental results.

research Transdermal delivery of mixnoxidil with block copolymer nanoparticles

253 citations , June 2004 in “Journal of Controlled Release”

The research observed that 40-nm self-assembled nanoparticles enhanced minoxidil penetration in hairy guinea pig skin compared to 130-nm nanoparticles, but this size effect was absent in hairless skin.

research Ethosomes: New Prospects in Transdermal Delivery

222 citations , January 2003 in “Critical Reviews in Therapeutic Drug Carrier Systems”

This review discusses the capabilities of ethosomes as drug delivery carriers and reports improved outcomes in a clinical study with an ethosomal acyclovir formulation.

research Transdermal delivery of mixnoxidil with block copolymer nanoparticles

181 citations , July 2004 in “Journal of controlled release”

In this study, researchers found that in hairy guinea pig skin, minoxidil delivered via 40-nm nanoparticles had higher skin penetration than 130-nm nanoparticles, indicating nanoparticle size affects permeation.

research Biocompatible nanoparticles and vesicular systems in transdermal drug delivery for various skin diseases

151 citations , November 2018 in “International Journal of Pharmaceutics”

This review discusses various nanoparticles and nanoemulsions being investigated for transdermal drug delivery and reports no clinical results; it highlights potential applications in treating alopecia, wound healing, psoriasis, and melanoma.

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Community Join

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community Hair Regrowth by Transdermal Dissolvable Microneedles Loaded with Rapamycin and Epigallocatechin Gallate Nanoparticles - PubMed

15 upvotes 4 years ago

The conversation discusses hair regrowth using dissolvable microneedles loaded with rapamycin and epigallocatechin gallate nanoparticles. Specific treatments mentioned include Minoxidil, finasteride, and RU58841.

community Oral minoxidil - how important is dermastamping?

10 months ago

A trans woman is using 10 mg oral minoxidil, dutasteride, and estradiol for hair regrowth and is also doing dermastamping despite the pain. Users discuss the benefits of dermastamping for serum absorption and hair follicle stimulation, with some expressing surprise at the high minoxidil dosage.

community 2 months on topical minoxidil and derma rolling

in Transgender 10 upvotes 9 months ago

A 19-year-old trans female has been using topical minoxidil and dermarolling for nearly two months, alongside oral minoxidil, finasteride, spironolactone, and estrogen. She noticed significant hair improvement after starting topical minoxidil and dermarolling.

community Trans guy with frontal hair loss - making sure I'm doing the right things.

5 upvotes 8 years ago

A trans man experiencing frontal hair loss is considering using finasteride and minoxidil, while also consulting a dermatologist. He is cautious about starting treatments before his appointment and is concerned about the effects of rapid weight loss on his hair.

community Is my current doseage viable? (Trans)

3 upvotes 10 months ago

The user is taking Dutasteride, Finasteride, Estradiol, Spironolactone, and Progesterone for hair regrowth and is considering adding Minoxidil and rosemary oil. They are experiencing some hair regrowth and are consulting a dermatologist to avoid a hair transplant.

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Learn

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learn Tretinoin

the gold standard retinoid in dermatology that's also helpful for hair regrowth alongside Minoxidil

learn Rapamycin

mTOR regulator and immunosuppressant used more recently for anti-aging and hair regrowth

learn Overview

learn Bicalutamide

Could bicalutamide help trans women regrow hair lost to testosterone? No study has tested bicalutamide for hair regrowth in trans women. In cisgender women the only randomized trial found it added nothing to minoxidil, and it is an off-label prescription drug that requires liver monitoring.

learn Alfatradiol

Does Alfatradiol work the same for women, men, and trans people? Almost all controlled data on topical alfatradiol comes from cisgender women, where it slowed hair loss rather than regrowing hair and was outperformed by minoxidil. No published controlled trial covers cisgender men, and none covers trans people at all — so the honest answer is that the difference has not been measured.

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Clinics

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