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GlossaryTumor Protein p63 (TP63)

protein crucial for epithelial tissue development and maintenance

Tumor Protein p63 (often referred to as p63 or TP63) is a protein that plays a crucial role in the development and maintenance of epithelial tissues, which are the layers of cells covering surfaces and lining cavities in the body. It is involved in regulating cell proliferation, differentiation, and apoptosis (programmed cell death). Mutations in the TP63 gene can lead to various developmental disorders and have been linked to certain types of cancer.

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research Tp63-Expressing Adult Epithelial Stem Cells Cross Lineage Boundaries Revealing Latent Hairy Skin Competence

8 citations, November 2020 in “Nature Communications”

Adult stem cells with Tp63 can form hair and skin cells when placed in new skin, showing they have hidden abilities for skin repair.

research A TP63 Mutation Causes Prominent Alopecia with Mild Ectodermal Dysplasia

2 citations, May 2020 in “The journal of investigative dermatology/Journal of investigative dermatology”

A TP63 gene mutation causes significant hair loss and mild skin, nail, and tooth abnormalities.

research Ectrodactyly, Ectodermal Dysplasia, and Cleft Lip/Palate Syndrome with Concomitant Lymphopenia: A Novel TP63 Mutation

February 2016 in “The journal of allergy and clinical immunology/Journal of allergy and clinical immunology/The journal of allergy and clinical immunology”

A new TP63 mutation was found in a baby with EEC syndrome, showing the need for TREC testing to check for immune issues.

research Rapp-Hodgkin Syndrome: A Review of Hair and Hair Color Aspects

25 citations, September 2005 in “Journal of the American Academy of Dermatology”

Rapp-Hodgkin syndrome, AEC, and EEC are different expressions of the same genetic disorder caused by TP63 gene mutations.

research GRHL3 Binding and Enhancers Rearrange as Epidermal Keratinocytes Transition Between Functional States

38 citations, April 2017 in “PLOS Genetics”

GRHL3 is important for controlling gene activity in skin cells during different stages of their development.

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