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community Looking for topical treatment recommendations

4 upvotes 5 years ago

The conversation discusses sourcing topical dutasteride for hair loss treatment, with mentions of Dr. Mwamba's products and Farmacia Prati as potential suppliers. Additional treatments like topical tocotrienols and botox are suggested as extensions to the regimen.

community Any supps/topicals you thought made a difference?

4 upvotes 5 years ago

The conversation discusses various hair loss treatments, with some users avoiding finasteride due to potential side effects and opting for alternatives like dermarolling, minoxidil, peppermint oil, and other natural remedies. Despite trying different supplements and oils, many users report limited success, with some eventually considering or using finasteride, dutasteride, or topical treatments for better results.

community What happened to that guy who’s been drinking topical minoxidil?!

in Chat 217 upvotes 1 year ago

A user tried various hair growth treatments, including drinking topical minoxidil, using oral minoxidil and finasteride, and applying GHK-Cu, growth hormone peptides, and liposomal sulforaphane. They experienced thicker hair, while others discussed the risks and benefits of these methods.

community Best science-backed supplements for androgenetic alopecia? Looking for real evidence

8 months ago

The conversation discusses treatments for androgenetic alopecia, focusing on evidence-based supplements to complement finasteride. Suggestions include oral minoxidil, saw palmetto, pumpkin seed oil, tocotrienols, and various other supplements, while emphasizing the importance of scientific backing and cautioning against saw palmetto if already using finasteride.

community Rate my treatment stack from 1-10

in Chat 1 year ago

The conversation discusses various hair loss treatments, with a focus on pyrilutamide, minoxidil, and alternatives to finasteride due to intolerance. Users suggest adding a DHT blocker like finasteride or dutasteride, and some recommend trying topical versions to reduce side effects.

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Research

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research A Systemic Review on Topical Marketed Formulations, Natural Products, and Oral Supplements to Prevent Androgenic Alopecia: A Review

14 citations , October 2020 in “Natural Products and Bioprospecting”

This review discusses current topical treatments, natural products, and complementary therapies for androgenetic alopecia, but it reports no new clinical results.

research NANOEMULGEL AS A RECENT DRUG DELIVERY SYSTEM

8 citations , December 2021 in “Military Medical Science Letters”

This review highlights the potential of nanoemulgel as a promising drug delivery system for lipophilic drugs, but presents no new experimental results; it discusses composition, preparation methods, and applications.

research A decade of progress in androgenetic alopecia management: Emerging therapies and multimodal strategies

December 2025 in “IP Indian Journal of Clinical and Experimental Dermatology”

This review reports that the treatment of androgenetic alopecia is shifting from single therapies to personalized, multimodal approaches incorporating both traditional and emerging pharmacologics, regenerative strategies, nutraceuticals, cosmeceuticals, and device-based interventions, with combination regimens showing improved outcomes.

research The Potential Application of Nanocarriers in Delivering Topical Antioxidants

January 2025 in “Pharmaceuticals”

This review discusses the role of nanocarrier systems, such as nanoemulsions and liposomes, in delivering antioxidants into the skin to counteract oxidative stress, highlighting recent advancements in topical antioxidant therapy through nanotechnology.

research Skin connective tissue and ageing

77 citations , July 2013 in “Best Practice & Research in Clinical Obstetrics & Gynaecology”

This review discusses the impact of menopause-related oestrogen deficiency on skin ageing and suggests that oestrogen use may improve collagen and skin elasticity, but it reports no clinical trial results.

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Learn

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learn Finasteride

Topical or oral? Choosing between pills and lotions according to your case. In studies, topical finasteride gave much lower blood levels of the drug than tablets but still lowered blood DHT, and whether it causes fewer side effects has not been established. There is no FDA-approved topical finasteride, and the FDA warned about compounded versions in April 2025.

learn Cetirizine

Is topical cetirizine effective for androgenetic alopecia in women? Topical cetirizine is not an approved product and its use for female-pattern hair loss is off-label. The evidence is one small pilot study in mixed-sex patients and one randomized trial in 66 women where cetirizine was added to minoxidil; it is unproven on its own.

learn Valproic acid

How is valproic acid being explored differently in topical hair products compared to its traditional oral medical use? Topical valproic acid is being studied for local effects on the hair follicle rather than the whole-body effects of the oral drug. The human evidence is one small randomized 24-week trial of an 8.3% spray; no topical valproate product is approved for hair loss.

learn Bicalutamide

Is topical bicalutamide a safer alternative to finasteride? There is no published human trial of topical bicalutamide for hair loss, and no licensed topical product exists, so it cannot be called safer than finasteride — or shown to work at all. Oral finasteride has decades of trial data with a documented side-effect profile, and topical finasteride has a phase III trial behind it.

learn Rapamycin

Does topical rapamycin actually help reactivate dormant hair follicles? No study in living people has shown that topical rapamycin reactivates hair follicles; the evidence is from mice and cultured follicles.

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