10 citations
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July 2021 in “European journal of pharmaceutics and biopharmaceutics” This study reported that larger caffeine nanocrystals, at 694 nm, increased caffeine bioavailability via transfollicular penetration compared to smaller nanocrystals, especially in long-term serum concentration measurements.
September 2025 in “medRxiv (Cold Spring Harbor Laboratory)” This study found that applying a topical scalp essence with Centella asiatica extracellular vesicles and growth factors significantly improved scalp health and hair growth compared to a placebo after 56 days.
December 2024 in “Skin Appendage Disorders” Researchers reviewed 13 clinical trials on non-prescription monotherapies like procyanidin and cetirizine for androgenetic alopecia, finding potential improvements in hair density and diameter, but emphasized the need for more robust trials to confirm efficacy and safety.
7 citations
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October 2024 in “AAPS PharmSciTech” This study developed a caffeine-loaded solid lipid nanoparticle gel, observing significant reduction in subcutaneous fat tissue thickness in histological tests compared to an untreated group, suggesting it could effectively treat cellulite as a promising nanocosmeceutical gel.
31 citations
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February 2019 in “International Journal of Cosmetic Science” This study found that ultraviolet radiation negatively affects hair follicle functions in human scalp skin, and caffeine application may provide some protective effects against this damage.