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Topical Application of Polygonum Multiflorum Extract Induces Hair Growth of Resting Hair Follicles Through Upregulating Shh and β-Catenin Expression in C57BL/6 Mice

research Topical application of Polygonum multiflorum extract induces hair growth of resting hair follicles through upregulating Shh and β-catenin expression in C57BL/6 mice

91 citations , April 2011 in “Journal of Ethnopharmacology”

This study found that Polygonum multiflorum extract may promote hair growth by inducing the anagen phase in the resting hair follicles of mice.

research Topical Application of the Synthetic Triterpenoid RTA 408 Protects Mice from Radiation-Induced Dermatitis

61 citations , April 2014 in “Radiation Research”

This study observed that topically applied RTA 408 reduced the severity of radiation-induced dermatitis in mice, with the highest dose significantly reducing and alleviating skin damage and associated inflammation.

research Topical Application of a Protein Kinase C Inhibitor Reduces Skin and Hair Pigmentation

60 citations , January 2004 in “The journal of investigative dermatology/Journal of investigative dermatology”

This study found that inhibiting PKC-β activity with bisindolylmaleimide reduces pigmentation in the skin and hair of guinea pigs and mice by preventing tyrosinase activation.

research The use of liposomes in the topical application of steroids

33 citations , May 1984 in “Journal of Pharmacy and Pharmacology”

This study found that while systemic absorption of DHT from liposomes was negligible, the topical biological effect was weaker compared to DHT dissolved in acetone on the female hamster flank organ model.

research Topical Application of Oleuropein Induces Anagen Hair Growth in Telogen Mouse Skin

32 citations , June 2015 in “PLOS ONE”

This study demonstrated that topical oleuropein induced hair growth in mice by activating the Wnt10b/β-catenin signaling pathway and increasing expression of several growth-related genes in skin tissue.

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Community Join

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community Prevention of age-related beard graying in humans by the topical application of Eriodictyon angustifolium extract

5 upvotes 4 years ago

Topical application of Eriodictyon angustifolium extract can prevent and reverse age-related beard graying and darken gray hair by increasing melanin production. Sterubin, a component of the extract, also promotes hair pigmentation and protects cells from DNA damage.

community Concerns regarding topical fin application

74 upvotes 2 months ago

Topical finasteride, specifically Fynzur spray, is used for diffuse thinning in long hair, but many find the cone applicator ineffective and suggest applying directly to the scalp. Some users recommend oral finasteride for more even results, while others combine it with minoxidil for better effectiveness.

community Topical minoxidil brand (and form of application) matters. You can be a hyper-responder to one product and a non-responder to another.

18 upvotes 1 year ago

Different minoxidil formulations affect hair growth and side effects. Higher propylene glycol and pH levels improve effectiveness but can cause scalp irritation.

community I think microneedling before topical application of finasteride (or dut) is a path we should investigate (for those of us who don't care about systemic absorption). Here's why...

20 upvotes 1 year ago

Microneedling before applying topical finasteride or dutasteride may enhance their effectiveness by increasing local absorption in the scalp, despite concerns about systemic absorption. Users discuss combining this method with oral treatments and minoxidil, noting potential benefits and side effects.

community Frequency/strength of topical minoxidil application

13 upvotes 2 years ago

The conversation discusses the effectiveness of Minoxidil (Min) for hair loss treatment. It concludes that applying a 5% solution once daily is sufficient, and applying it twice daily doesn't provide much more benefit. However, if a higher concentration is beneficial, it can be achieved by more frequent application.

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Learn

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learn Linoleic Acid

Is it better to take linoleic acid as a supplement or apply it topically for hair growth? Topical application of linoleic acid is generally more effective for hair growth than supplements.

learn Clascoterone

a novel topical treatment that inhibits DHT on androgen receptors

learn zinc PCA

Should zinc be taken orally or applied topically for better results in hair growth? Oral zinc supplementation is generally more effective for promoting hair growth than topical application.

learn Melatonin

hormone commonly taken for sleep aid has some topical benefits for hair

learn Verteporfin

chemical that might completely regrow follicles from hair transplant extractions

learn Alfatradiol

a synthetic estrogen used topically as an anti-androgen

learn Latanoprost

glaucoma medication with hair follicle stimulant effects

learn Finasteride

Topical or oral? Choosing between pills and lotions according to your case. Topical finasteride offers localized treatment with fewer systemic side effects than oral finasteride.

learn Cetirizine

Is topical cetirizine effective for androgenetic alopecia in women? Topical cetirizine is not an approved product and its use for female-pattern hair loss is off-label. The evidence is one small unblinded pilot study in mixed-sex patients and one randomized trial in 66 women where cetirizine was added to minoxidil; it is unproven on its own.

learn Estradiol

How does topical Estradiol compare to oral Estradiol in treating alopecia? Topical estradiol delivers hormone to the scalp with less systemic exposure, but evidence is thin and it is still a hormone. It needs a doctor's supervision, and people with estrogen-sensitive cancers must not use it without medical approval.

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