91 citations
,
April 2011 in “Journal of Ethnopharmacology” This study found that Polygonum multiflorum extract may promote hair growth by inducing the anagen phase in the resting hair follicles of mice.
61 citations
,
April 2014 in “Radiation Research” This study observed that topically applied RTA 408 reduced the severity of radiation-induced dermatitis in mice, with the highest dose significantly reducing and alleviating skin damage and associated inflammation.
60 citations
,
January 2004 in “The journal of investigative dermatology/Journal of investigative dermatology” This study found that inhibiting PKC-β activity with bisindolylmaleimide reduces pigmentation in the skin and hair of guinea pigs and mice by preventing tyrosinase activation.
33 citations
,
May 1984 in “Journal of Pharmacy and Pharmacology” This study found that while systemic absorption of DHT from liposomes was negligible, the topical biological effect was weaker compared to DHT dissolved in acetone on the female hamster flank organ model.
32 citations
,
June 2015 in “PLOS ONE” This study demonstrated that topical oleuropein induced hair growth in mice by activating the Wnt10b/β-catenin signaling pathway and increasing expression of several growth-related genes in skin tissue.
31 citations
,
September 2011 in “European journal of pharmaceutics and biopharmaceutics” This study found that biodegradable PLA particles released fluorochromes in a time-dependent manner on human skin, with BP-PLA particles releasing rapidly and DiAsp-PLA particles providing sustained release and accumulation in hair follicles.
28 citations
,
December 2005 in “Journal of cosmetic dermatology” This study found that 0.7% apple procyanidin oligomers applied externally for six months significantly increased hair growth in men with male pattern baldness compared to placebo, with no observed adverse effects.
24 citations
,
April 2005 in “The Journal of Dermatology” This study found that 2% ketoconazole solution stimulated hair growth significantly in a mouse model, suggesting potential benefits for male pattern hair loss.
24 citations
,
September 2001 in “Journal of Dermatological Science” This study found that cyclophosphamide-induced hair follicle damage in C3H mice could be remodelled into intact anagen hair follicles with topical cyclosporin A, especially in anagen IV stage follicles.
22 citations
,
July 2006 in “Indian Journal of Pharmaceutical Sciences” This study evaluated four minoxidil gel formulations for alopecia treatment, finding similar drug release across membranes and stability over three months, with no skin irritation observed in mice.
20 citations
,
April 2016 in “Journal of Cosmetic Dermatology” In this study, topical methyl vanillate application increased hair count and hair mass index in women with androgenetic alopecia by enhancing WNT10B expression, suggesting a potential new treatment strategy.
19 citations
,
November 2023 in “npj Regenerative Medicine” This study found that synthetic melanin particles applied topically in mouse injury models improved wound healing, showing potential as a therapy for accelerated healing, including in human skin explants.
15 citations
,
December 2016 in “Advanced Pharmaceutical Bulletin” This study found that N-acetyl-glucosamine-loaded nanostructured lipid carriers showed promise for skin lightening in healthy volunteers by reducing melanin distribution.
15 citations
,
July 2010 in “Journal of Allergy and Clinical Immunology” This study found that in mouse models, the novel NF-κB inhibitor DHMEQ improved symptoms of atopic dermatitis as effectively as tacrolimus or betamethasone.
14 citations
,
July 1977 in “PubMed” This study reported that a 19-year-old man's essential fatty acid deficiency was reversed with daily topical application of linoleic acid, improving clinical symptoms and normalizing certain fatty acid levels.
10 citations
,
July 2021 in “European journal of pharmaceutics and biopharmaceutics” This study reported that larger caffeine nanocrystals, at 694 nm, increased caffeine bioavailability via transfollicular penetration compared to smaller nanocrystals, especially in long-term serum concentration measurements.
8 citations
,
February 2005 in “International Journal of Cosmetic Science” The study found that applying Bifidobacterium-fermented soy milk extract to human skin significantly reduced the decline in skin elasticity, suggesting its potential as a cosmetic ingredient to prevent skin aging.
8 citations
,
April 1988 in “Journal of endocrinological investigation” This study found that topically administered spironolactone in healthy volunteers resulted in no detectable systemic absorption or changes in related hormone levels over 72 hours, indicating local effect only.
7 citations
,
January 2015 in “International Journal of Trichology” This case report describes a woman who experienced frontal edema after topical minoxidil application following mesotherapy, noting that excessive absorption of minoxidil may cause localized vasodilatory side effects.
5 citations
,
January 2023 in “Journal of Cosmetic Dermatology” This study found that microbotox, especially when injected intradermally, effectively reduces enlarged facial pores with higher patient satisfaction and longer-lasting results compared to its topical application after microneedling.
5 citations
,
June 2012 in “The journal of investigative dermatology/Journal of investigative dermatology” This study found that applying topical thymidine dinucleotide (pTT) to newborn mice before UV exposure delayed and reduced melanoma development compared to untreated controls.
5 citations
,
November 2007 in “British journal of nursing” This article discusses the importance of nurses' understanding of topical emollient therapy for patients with eczema, but it does not provide new clinical results.
4 citations
,
March 2018 in “Daehan han'yi hag'hoeji/Journal of Korean medicine” This study found that topical application of Astragalus membranaceus extract induced hair regrowth and reduced immune response markers in mice with natural hair loss.
4 citations
,
June 2017 in “Irish veterinary journal” In this study, a single application of a 10 mg/mL deltamethrin-based solution effectively reduced lice infestations by 98% to 100% in treated horses and prevented new infestations for up to a month, without adverse events reported.
4 citations
,
January 1965 in “THE JOURNAL OF VITAMINOLOGY” In this study, applying 0.5% vitamin E lotions on rabbits accelerated hair growth and increased it up to 2.4 times compared to controls within four weeks.
2 citations
,
February 2016 in “British Journal of Dermatology” This study found that topical bimatoprost significantly improved eyelash growth in individuals with idiopathic and chemotherapy-induced eyelash hypotrichosis compared to a vehicle treatment.
1 citations
,
January 2025 in “Journal of Clinical and Investigative Dermatology” This study observed significant improvements in hair loss and hair density among adults using USPlus DERM Topical serum daily for 12 weeks, with 90.9% of participants noticing better hair loss/density and rating satisfaction at an average of 7.7 out of 10.
1 citations
,
January 1994 in “Drug Development and Industrial Pharmacy” This study suggests that certain combinations of topical radioprotectors and vehicles can reduce radiation-induced hair loss in mice, with effectiveness varying by radiation dose and vehicle type.
1 citations
,
November 1981 in “PubMed” No clear conclusion available.
April 2026 in “Frontiers in Bioengineering and Biotechnology” This study found that a cellulose membrane significantly shortened the healing time and reduced the ulcer area in patients with chronic venous leg ulcers compared to a standard antimicrobial dressing.