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Glossary TNF inhibitors

medications that block inflammation-causing proteins in autoimmune diseases

TNF inhibitors, also known as Tumor Necrosis Factor inhibitors or TNF blockers, are medications that reduce inflammation by blocking the activity of TNF-alpha, a substance in the body that causes inflammation and can lead to immune system diseases. They are commonly used to treat autoimmune conditions such as rheumatoid arthritis, psoriasis, and inflammatory bowel disease by preventing the immune system from attacking healthy tissues.

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Research

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research TNF inhibitor induced alopecia: an unusual form of psoriasiform alopecia that breaks the Renbök mold

9 citations , January 2017 in “Dermatology Online Journal”

This study describes a distinctive hair loss pattern with features of psoriasis and alopecia areata linked to TNF-α inhibitors, noting various management options despite the lack of consensus guidelines.

research TNF-α Inhibitor-Induced Psoriasis and Psoriatic Alopecia in Adolescent with Ulcerative Colitis: Clinical Case

3 citations , November 2023 in “Вопросы современной педиатрии”

This case study described a 17-year-old with paradoxical psoriasis and ulcerative colitis, triggered by TNF-α inhibitor therapy, who experienced clinical improvement and hair regrowth after switching to ustekinumab, which the authors note aligns with existing data on its effectiveness for these conditions.

research Immune-Mediated Skin Reactions Induced by Recombinant Antibodies and Other TNF-Alpha Inhibitors

2 citations , February 2018 in “InTech eBooks”

This article discusses adverse immune-mediated skin reactions associated with TNF-alpha inhibitors, highlighting paradoxical reactions such as psoriasis that occur despite being treated with medications intended to alleviate the condition.

The Development of Universal Alopecia During Therapy With TNF-α Inhibitors in Patients With Ankylosing Spondylitis: Description of Three Cases

research The development of universal alopecia during therapy with TNF-α inhibitors in patients with ankylosing spondylitis: description of three cases

October 2021 in “Rheumatology Science and Practice”

The article presents three clinical cases of universal alopecia developing during TNF-α inhibitor therapy and discusses possible mechanisms and the role of pro-inflammatory cytokines.

Oral Contraceptive Pill Treatment Alters Gene Expression of Inflammatory Markers in Polycystic Ovary Syndrome Women

research Oral contraceptive pill (OCP) treatment alters the gene expression of intercellular adhesion molecule-1 (ICAM-1), tumor necrosis factor-α (TNF-α), monocyte chemoattractant protein-1 (MCP-1) and plasminogen activator inhibitor-1 (PAI-1) in polycystic ovary syndrome (PCOS) women compared to drug-naive PCOS women

2 citations , February 2023 in “BMC women's health”

In this study, oral contraceptive use in women with PCOS increased the expression of certain inflammatory gene markers, which were positively associated with metabolic abnormalities.

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Community Join

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community Prolactin the Cause of Hair Loss? ABS-201 the Cure?

29 upvotes 2 months ago

Prolactin may contribute to hair loss, but targeting its receptor won't cure androgenetic alopecia. ABS-201 could be a useful alternative or adjuvant therapy, similar to JAK inhibitors, but not more effective than HMI-115.

community Finasteride does deplete important nuero-active steroids

11 upvotes 3 years ago

Finasteride can reduce neuroactive steroids, causing side effects like depression, anxiety, and sexual dysfunction. Some users experience persistent symptoms after stopping finasteride, while others use alternative treatments like topical solutions.

community Dutasteride actually has different half lives depending on dose

in Research/Science 37 upvotes 1 year ago

Dutasteride's half-life varies with dosage, and lower doses can be effective with fewer side effects compared to finasteride. Some users report different side effects with dutasteride and finasteride, and extreme dosages of dutasteride are unnecessary and potentially harmful.

community What is the real impact of dutasteride on neurosteroids? A little review of 2 scientific datas

in Research/Science 21 upvotes 2 years ago

Dutasteride at 0.5 mg/day does not significantly alter allopregnanolone levels, but higher doses (2.5 mg/day) do. Dutasteride may also have anti-neuroinflammatory effects, but the impact on neurosteroids is still debated.

community Reducing Fibrosis in Hair Loss: Topical Pirfenidone

59 upvotes 5 months ago

Topical pirfenidone is highlighted as an effective anti-inflammatory and anti-fibrotic treatment for hair loss, particularly in addressing perifollicular fibrosis, which may enhance the effectiveness of standard treatments like finasteride and minoxidil. The user also uses calcipotriol, MCT oil, ciclopirox shampoo, and benzoyl peroxide shampoo as part of their regimen.

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Learn

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learn Neem Oil

natural substance from Neem tree with medicinal and pesticidal properties

learn Tofacitinib

a JAK inhibitor for alopecia areata and other autoimmune conditions

What types of hair loss conditions are most commonly associated with tofacitinib use in clinical settings? Published studies link tofacitinib mainly to alopecia areata and its severe variants — as an off-label drug being studied for them, not as a cause of hair loss. The evidence is mostly small, open-label or retrospective, and relapse after stopping is commonly reported.

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Clinics

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Experts

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95
Dermatologist
Dr. Tanvi Vaidya, MD, MBBS, MRCP
Thane, Maharashtra, India

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Dr. Tanvi Vaidya, MD, MBBS, MRCP