This narrative review highlights the critical role of intracrine hormone production in peripheral tissues, suggesting that continuous-release subcutaneous testosterone pellet therapy may offer a more effective symptom-driven approach for aging populations, though large-scale randomized controlled trials are needed for confirmation.
21 citations
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November 2010 in “Talanta” This study reported the development of a novel and reliable liquid chromatographic method to measure testosterone and epitestosterone in human urine, offering sensitive detection for doping control.
July 2026 in “Pharmacological Research - Modern Chinese Medicine” In this study, researchers developed and optimized a smartlipid nanocarrier gel formulation of berberine that significantly reduced hair loss and promoted faster hair regrowth in a testosterone-induced hair loss model, showing potential as an effective treatment for androgenetic alopecia.
32 citations
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December 2017 in “Journal of Drug Delivery Science and Technology” This study found that co-delivery of minoxidil and caffeine in transfersomes with an optimized polysorbate formulation enhanced hair length and weight in vivo.
July 2026 in “International Journal of Molecular Sciences” This study found that TSG-enriched Polygonum multiflorum extract, optimized through microwave-assisted and chromatographic methods, promotes hair regrowth in a mouse model of androgenetic alopecia via 5α-reductase inhibition and Wnt/β-catenin pathway activation, suggesting its potential as a natural treatment.
