research Association Between Genetically Predicted Leukocyte Telomere Length and Non-Scarring Alopecia: A Two-Sample Mendelian Randomization Study
Shorter telomeres in white blood cells may increase the risk of a common type of hair loss.
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research Novel Aspects of Age-Protection by Spermidine Supplementation Are Associated with Preserved Telomere Length
Spermidine helps protect against aging by preserving telomere length.
research Telomere Dynamics and Telomerase in the Biology of Hair Follicles and Their Stem Cells as a Model for Aging Research
Hair follicle studies suggest that maintaining telomere length could help treat hair loss and graying, but it's uncertain if mouse results apply to humans.
research The TRF1 telomere protein is essential for the generation and maintenance of iPS cells and marks both pluripotent and adult stem cells
The study demonstrated that the telomere repeat binding factor 1 (TRF1) was crucial for the generation and maintenance of induced pluripotent stem (iPS) cells and marked both pluripotent and adult stem cells. TRF1 was found to be essential for maintaining small intestine homeostasis and was highly expressed in adult stem cell compartments, including hair follicle stem cells. The research used a reporter mouse model with TRF1 fused to eGFP, revealing that TRF1 expression was independent of telomere length. High levels of TRF1 in iPS cells correlated with increased pluripotency, and TRF1 was identified as a direct target of the transcription factor Oct3/4, linking it to pluripotency. These findings positioned TRF1 as a novel marker for stem cells and a key factor in pluripotency.
research New Intranasal and Injectable Gene Therapy for Healthy Life Extension
Gene therapy in mice increased lifespan and improved health without causing cancer.
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5 / 7 resultscommunity How ET-02 Works. Also no proof that it's better than Minoxidil. At least for now.
ET-02, a PAI-1 inhibitor, is not proven to be more effective than Minoxidil for hair loss. Other treatments like finasteride, dutasteride, PP405, and AMP-303 are also discussed, focusing on cellular senescence and oxidative stress.
community 2.5 yrs progress: Min + dermaroll + niz
A user's 2.5 year hair loss progress with Minoxidil, dermarolling, and Nizoral treatments, as well as taking biotin and a multivitamin supplement, with the intention of trying DIY topical finasteride in the future.
community M26 - 9 months after hair transplant! AMA
A user who underwent a hair transplant in Istanbul to reduce balding, and the discussion of various treatments such as finasteride and growth hormone for preventing further hair loss.
community Is this real chat? Finasteride -> fountain of youth and longevity drug?
Finasteride is discussed as a hair loss treatment with benefits like reduced prostate enlargement and skin aging, but it is not seen as a "fountain of youth." Users report mixed experiences, including side effects like decreased libido and dry eyes.
community In my opinion baldness is more prevalent now and it's being ignored..
The conversation is about the prevalence of baldness among young men and the potential factors contributing to it. Specific treatments mentioned include minoxidil and finasteride.