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community After about 3 months of 2mg Estradiol (Sublingual) and 2.5mg Minox (Oral) daily

in Progress Pictures 160 upvotes 10 months ago

A person transitioning is using 2mg sublingual estradiol and 2.5mg oral minoxidil daily for hair regrowth, noting significant progress in three months. They plan to increase estrogen dosage and consider adding dutasteride, discussing the effects and challenges of transitioning.

community Yet another hrt update (4 months estradiol and spiro + > 4 years of fin and min) (you should absolutely not take estradiol and spiro if you look manly and want to continue to look manly)

4 upvotes 2 years ago

The conversation discusses hair loss treatments, including finasteride, minoxidil, estradiol, and spironolactone, with a focus on their effects on hair regrowth and gender transition. The original poster shares their personal experience with these treatments, emphasizing that estradiol and spironolactone should not be used by those who want to maintain a masculine appearance.

community [M31] 2+ years progress on Oral Dutasteride and Sublingual Minoxidil

in Progress Pictures 67 upvotes 2 years ago

A user shared their 2+ years progress on Oral Dutasteride and Sublingual Minoxidil for hair loss. Another user asked about the form of Minoxidil used sublingually.

community Feel like im not making process. Had insane shed. (Min/Fin/HRT)

in Progress Pictures 5 upvotes 5 months ago

The user started using oral minoxidil and estradiol in August 2025, added finasteride in December, and experienced significant hair shedding in February/March. They switched to estradiol injections and are considering their hair washing routine, while another user suggested consulting a dermatologist and possibly trying dutasteride.

community 15 Months Ago vs 15 Minutes Ago (Fin + Min + Spiro + E)

43 upvotes 2 months ago

The user experienced significant hair regrowth using spironolactone, estradiol, minoxidil, and finasteride while transitioning. They noted reduced libido and increased grogginess as side effects.

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Research

5 / 513 results

research Hormonal Treatment of Transgender Women with Oral Estradiol

37 citations , May 2018 in “Transgender health”

This study found that oral estradiol was generally effective in achieving target 17-β estradiol levels in transgender women, but often failed to suppress testosterone adequately, with variability in individual responses.

research Treatment of androgenetic alopecia in transgender people receiving testosterone therapy with sublingual minoxidil: A randomized, double-blind, placebo-controlled clinical trial

May 2026 in “Journal of the American Academy of Dermatology”

In this study, sublingual minoxidil was found to be a safe and effective treatment for increasing hair growth in transgender individuals with mild androgenetic alopecia who are undergoing full-dose testosterone therapy.

research Rheumatologic Manifestations of Pregnancy

3 citations , November 2010 in “Rheumatic Diseases Clinics of North America”

This article reviews how normal pregnancy changes can mimic rheumatologic disorders, emphasizing the importance of distinguishing these from true autoimmune inflammation, but reports no new evidence.

research Medical Options for Care of Gender Diverse and Transgender Youth

17 citations , February 2020 in “Journal of Pediatric and Adolescent Gynecology”

This review discusses medical interventions that reproductive health experts can provide to transgender and gender diverse youth and reports no new clinical results.

research Bicalutamide does not raise transaminases in comparison to alternative anti-androgen regimens among transfeminine adolescents and young adults: a retrospective cohort study

February 2024

In this study, bicalutamide at low doses was not linked to significant liver enzyme changes compared to other androgen-blocking treatments in transfeminine adolescents and young adults, suggesting its safety with careful monitoring for this population over one year.

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Learn

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learn Ethinylestradiol

learn Ethynylestradiol

learn Estradiol

Estrogen hormone, prescribed in tablet, patch and gel forms

Is applying Estradiol directly to the scalp effective for hormone-related hair thinning? There are no good-quality trials showing that estradiol applied to the scalp treats hormone-related thinning. Skin-applied estradiol can still enter the bloodstream and pass to others through contact.
Why is Estradiol used to treat hair loss in women and transgender people undergoing hormone therapy? Estradiol is used within supervised hormone therapy and may slow hormone-related hair loss in some women and trans women, but the evidence is limited and it carries serious whole-body risks.
How does topical Estradiol compare to oral Estradiol in treating alopecia? No study has compared topical and oral estradiol for hair loss, and estradiol applied to skin is still absorbed into the blood. Either form needs a doctor's supervision, and people with estrogen-sensitive cancers must not use it without medical approval.

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