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research P-421 ASSOCIATION BETWEEN STRESS-RELATED HORMONE LEVELS IN HAIR AND SUBJECTIVE MENTAL HEALTH IN JAPANESE WORKERS

July 2024 in “Occupational Medicine”

This study found that among Japanese full-time employees, cortisol levels in hair were negatively associated with aversive coping and emotional support-seeking tendencies, while dehydroepiandrosterone levels were linked to job confidence.

research Stress-related skin disorders

67 citations , July 2016 in “Reviews in Endocrine and Metabolic Disorders”

This review discusses the complex relationship between stress and various skin conditions, highlighting the role of the skin in the stress response and the brain-skin communication pathways, but reports no new research findings.

research The Mechanisms and Management of Age-Related Oxidative Stress in Male Hypogonadism Associated with Non-communicable Chronic Disease

16 citations , November 2021 in “Antioxidants”

This review examines the role of oxidative stress in male hypogonadism associated with noncommunicable chronic diseases and discusses various management strategies, but it presents no new clinical findings.

research Exploring the Antioxidative Effects of Ginger and Cinnamon: A Comprehensive Review of Evidence and Molecular Mechanisms Involved in Polycystic Ovary Syndrome (PCOS) and Other Oxidative Stress-Related Disorders

24 citations , March 2024 in “Antioxidants”

In this review, researchers reported that cinnamon and ginger supplementation may benefit PCOS patients by improving hormonal status, lipid profiles, obesity, and insulin resistance through oxidative stress and inflammation reduction.

research Corticotropin-releasing hormone inhibits autophagy by suppressing PTEN to promote apoptosis in dermal papilla cells

April 2025 in “Annals of Medicine”

This study suggests that the key mechanism of stress-related hair loss involves CRH-induced PTEN loss, which reduces autophagy and increases apoptosis in dermal papilla cells, highlighting potential therapeutic targets like PTEN activation or autophagy enhancement.

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learn Vitamin B6

Is Vitamin B6 helpful for stress-related or hormonal hair loss? Vitamin B6 may support overall health but lacks strong evidence for preventing hair loss.

learn Lavender

Is lavender effective for hormonal hair loss or just stress? No study has tested lavender for stress-related or hormonal hair loss in people; the hair-growth evidence is one mouse study. Case reports link lavender products to breast growth in children, so keep them away from children.

learn Caffeine

Stimulant used in hair shampoos and lotions

learn Neem Oil

Oil from the neem tree, used in traditional remedies

learn Dutasteride

5-alpha reductase inhibitor that blocks both enzyme types, a stronger DHT blocker than finasteride

learn procapil

Does pairing Procapil with antioxidants help stress-related hair thinning? No study has tested Procapil with antioxidants for stress-related shedding; evidence for Procapil itself is limited to the supplier's own tests and small combination studies.

learn Vitamin B5

Is Vitamin B5 beneficial for people experiencing stress-related or nutritional hair loss? Vitamin B5 is not proven to help with stress-related or nutritional hair loss.

learn PP405

Can PP405 help bald patches caused by stress? PP405 is an experimental topical gel from Pelage Pharmaceuticals that inhibits the mitochondrial pyruvate carrier; its registered Phase 2 trial (NCT06393452) tested it once daily in 78 adults with pattern hair loss, for safety and tolerability. It is not approved, not for sale, and has not been studied in alopecia areata or stress-related shedding.

Community Join

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community A stress hormone has been found to signal through skin cells to repress the activation of hair-follicle stem cells in mice

30 upvotes 5 years ago

Stress can lead to hair loss by affecting hair-follicle stem cells, and this loss is harder to recover from if one has male pattern baldness (MPB). Treatments like finasteride and minoxidil are used to address hair loss, but stress-related hair loss differs from androgenic alopecia.

community Could organic oils help out my old mom with her thinning hair?

1 upvotes 3 months ago

The conversation discusses hair thinning in an older woman, suggesting that organic oils like rosemary or argan oil are unlikely to help if the hair loss is due to stress or hormonal changes. It highlights that hair loss in older women is often related to hormonal changes during menopause.

community Acute shedding episodes. Had telogen effluvium last year. Remission for a few months(thought I was over the shedding stuff 🥲). Now if I have any major stress days, THAT day I get a major shed and a few days after.

4 upvotes 1 year ago

The user experiences immediate hair shedding linked to stress, unlike typical telogen effluvium, and is seeking answers. A suggestion was made to use spironolactone and topical minoxidil to address potential DHT-related shedding.

community Need Help Please! It's about Exosome therapy and my hair fall. If you have any questions, feel free to ask!

in Treatment 1 upvotes 6 months ago

A person experienced hair loss due to stress, hormonal changes, and possibly genetics, and tried treatments like minoxidil, finasteride, and dutasteride. They are now considering exosome therapy but are unsure about its effectiveness and which dermatologist to trust.

community The ending of alopecia? Corticosterone inhibits GAS6 to govern hair follicle stem-cell quiescence

63 upvotes 4 years ago

Corticosterone inhibits GAS6, affecting hair follicle stem-cell activity, with potential implications for stress-related hair loss. Ashwagandha and Vitamin K are suggested for reducing cortisol, but their effectiveness is debated.

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