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a signaling molecule from dermal papilla cells being actively researched
Research
5 / 1000+ resultsresearch An Evaluation of Collagen Peptide for Transdermal Delivery Using Strat-M Membrane and Excised Mouse Skin
This study evaluated the transdermal delivery of collagen peptides using Strat-M® membrane and excised mouse skin. The results indicated that the transdermal rate of collagen peptides increased linearly over time for both methods, with different concentrations affecting the cumulative transmission. Among the tested peptides, CP500 showed the highest cumulative transmission per unit area and transdermal rate. The study found a strong correlation (R² > 0.98) between the cumulative transmission through Strat-M® and excised mouse skin, suggesting that Strat-M® can effectively replace excised mouse skin for in vitro transdermal experiments. These findings can assist formulators in the pharmaceutical, personal care, and cosmetic industries in selecting appropriate vehicles during early development stages.
research Are We Ready to Measure Skin Permeation of Modern Antiaging GHK–Cu Tripeptide Encapsulated in Liposomes?
More research is needed to effectively measure how well GHK–Cu in liposomes penetrates the skin.
research Formulation and Development of Adapalene Topical Nanohydrogel Using Different Surfactants and Cosurfactants for Anti-Acne Activity: In Vitro and Ex Vivo Evaluation
The study developed and evaluated an adapalene nanohydrogel (ADP-NH) using different surfactants and cosurfactants for anti-acne activity. The formulation with Tween-80 (NH-Tween-80) showed superior in vitro and ex vivo permeability compared to those with sodium lauryl sulphate (NH-SLS), glycerol (NH-glycerol), and a control solution. NH-Tween-80 demonstrated significantly higher adapalene permeation through both Strat-M® membrane and Wistar rat skin, and its ex vivo permeability was 3.38 times greater than a conventional market gel. Stability tests over 6 months showed NH-Tween-80 maintained 99.25% drug content without physical changes, unlike NH-SLS and NH-glycerol, which showed color changes. The study concluded that NH-Tween-80 is a promising stable formulation for treating acne vulgaris.
research Interconnected Polymers Technology (IPSTiC): An Effective Approach for the Modulation of 5α-Reductase Activity in Hair Loss Conditions
A new anti-baldness patch effectively treats hair loss by blocking enzymes linked to the condition.
research The Use of Biodegradable Microneedle Patches to Increase Penetration of Topical Steroid for Prurigo Nodularis
Biodegradable microneedle patches help topical steroids work better for prurigo nodularis.
Community Join
5 / 1000+ resultscommunity A little over two years on Dut
A 23-year-old male has been using Dutasteride for over two years to address hair thinning, with some success in temple regrowth but continued thinning on top. He is considering adding Minoxidil to his routine and is contemplating lifestyle changes like quitting smoking and drinking to improve hair density.
community [Update] My Final Results – Finasteride, Minoxidil & Microneedling Journey 2020-25
The user successfully regrew hair using Finasteride, Minoxidil, and microneedling, achieving thicker hair and a fuller hairline. They recommend this method over hair transplants, highlighting the importance of patience and consistency.
community Started fin a month ago, feel like my hair is taking a drastic nosedive, is this a good sign?
The user started finasteride a month ago and experienced significant hair shedding, which is considered a sign that the treatment is working. Many users suggest combining finasteride with minoxidil and possibly shaving the head to manage the shedding phase.
community 35m 1.5 months on oral fin/min is it too good to be true?
A 35-year-old man, balding since 18, has seen growth of small, almost white hairs all over his scalp after 1.5 months on oral finasteride and minoxidil. Users suggest sticking with the treatment for a year, adding microneedling, and potentially trying RU58841 or dutasteride.
community Fighting Hair loss AND Grey Hair
The user is treating hair loss with topical Minoxidil, Finasteride, RU58841, microneedling, and Ketoconazole. For grey hair, they use L-Cysteine, L-Methionine, and PABA, and have noticed some re-pigmentation.