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signaling protein that, when suppressed, may grow hair by reducing inflammation and stem cell loss
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research Stem Cell Quiescence Acts as a Tumor Suppressor in Squamous Tumors
Inactive hair follicle stem cells help prevent skin cancer.
research Understanding Cancer Cells of Origin in Cutaneous Tumors
The document concludes that identifying the specific cells where skin cancers begin is important for creating better prevention, detection, and treatment methods.
research Increased Lactate Dehydrogenase Activity Is Dispensable in Squamous Carcinoma Cells of Origin
High lactate dehydrogenase activity is not necessary for the growth of squamous cell carcinoma.
research Decision letter: Loss of Dnmt3a and Dnmt3b does not affect epidermal homeostasis but promotes squamous transformation through PPAR-γ
The study found that the loss of DNA methyltransferases Dnmt3a and Dnmt3b did not impact epidermal homeostasis but did promote squamous transformation. Specifically, the absence of Dnmt3a increased the number of carcinogen-induced squamous tumors, while the combined loss of Dnmt3a and Dnmt3b led to more aggressive and metastatic squamous carcinomas. Dnmt3a was shown to promote epidermal differentiation and inhibit lipid metabolism genes, including PPAR-γ, with PPAR-γ inhibition partially preventing increased tumorigenesis due to Dnmt3a deletion. The study highlighted the protective role of Dnmt3a and Dnmt3b against tumorigenesis and the potential of targeting PPAR-γ in squamous carcinomas.
research Author response: Loss of Dnmt3a and Dnmt3b does not affect epidermal homeostasis but promotes squamous transformation through PPAR-γ
The study by Rinaldi et al. found that while Dnmt3a and Dnmt3b were not necessary for normal epidermal homeostasis in mice, their loss had significant effects on tumorigenesis. Specifically, the absence of Dnmt3a increased the initiation of squamous tumors, and the combined loss of both Dnmt3a and Dnmt3b led to more aggressive and metastatic squamous carcinomas. Dnmt3a promoted the expression of epidermal differentiation genes and inhibited lipid metabolism genes, including PPAR-γ. Inhibition of PPAR-γ reduced tumorigenesis in the absence of Dnmt3a, indicating that Dnmt3a and Dnmt3b played protective roles against tumorigenesis and that squamous carcinomas were sensitive to PPAR-γ inhibition.
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4 / 4 resultscommunity Just found a little hard lump under my left nipple, it’s over
A user experienced a hard lump under their nipple and increased hair loss after four months of finasteride. They are concerned about the lump and plan to stop the treatment.
community I find it crazy how some people like this bloke have 0 DHT sensitivity. He is on grams of anabolic steroids and has a full, thick head of hair. I wish all of on here had this guys hair genes lol
The conversation is about hair loss and the possibility of maintaining a full head of hair while using anabolic steroids. Some users believe that having good hair genes and taking hair loss protocols can help prevent hair loss while on steroids.
community Is There Any Chance Of Cancer In Follicle Neogenesis through Microneedling?
The conversation discusses concerns about the potential risk of cancer from creating new hair follicles through microneedling, due to stem cell division. Specific treatments mentioned include microneedling, caffeine-containing anti-hair loss shampoos, and other unspecified topicals.
community PP405 Drug in Action: Picture From Official Company Website
PP405 shows promise for hair follicle reactivation with minimal side effects. Users recommend continuing Minoxidil and Finasteride until more results are confirmed.