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In this narrative hypothesis-driven overview, the authors propose reframing rosacea as a neuroimmune disorder, highlighting the interconnected role of the skin-gut-brain axis, particularly central nervous system involvement alongside gut microbiota and neurogenic inflammation, to emphasize the need for multidisciplinary therapeutic approaches.

This review found that microbiota-targeted interventions, particularly certain strains of probiotics, are associated with improvements in skin conditions, most notably in pediatric atopic dermatitis, but their efficacy varies across other dermatological diseases.

This study found that while nicotinic acid significantly inhibited human sebaceous organoid growth in vitro, the predicted skin concentrations from gut microbiome-derived levels were far below the effective dose, suggesting high oral doses would be necessary for therapeutic effects.

This study introduces the concept of a "gut–brain–skin axis" where ingesting a specific Lactobacillus strain in mice may reduce stress-induced skin inflammation and hair growth inhibition.

Lactiplantibacillus plantarum ZJUIDS51 can help regrow hair and improve scalp health in androgenic alopecia.