15 citations
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February 2020 in “Journal of Investigative Dermatology” Ceramide Synthase 4 is crucial for healthy skin barrier function.
5 citations
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February 2025 in “Frontiers in Immunology” This study highlights emerging research on lactate's biological roles in skin health, emphasizing its function as a signaling molecule that regulates skin barrier and immunity, and notes its therapeutic potential for skin conditions such as tumors and inflammatory diseases.
9 citations
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August 2021 in “International journal of molecular sciences” This study found that loss of epidermal PPARγ in mice altered the expression of many genes related to skin inflammation, keratinization, and sebaceous gland function, indicating its key role in maintaining skin homeostasis.
84 citations
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May 2008 in “Biological Chemistry” This review discusses the roles of human tissue kallikreins in skin physiology and pathology and reports no new findings, emphasizing their potential involvement in various skin functions and conditions.
January 2014 in “eScholarship (California Digital Library)” In this study, researchers observed that TLR3 and scavenger receptors play key roles in skin barrier repair following UVB damage, contributing to our understanding of cellular responses to skin injury.