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research Accelerated senescence in skin in a murine model of radiation-induced multi-organ injury

19 citations , February 2017 in “Journal of radiation research”

This study found that high-dose radiation can induce accelerated cellular senescence, inflammation, and loss of epithelial stem cells in mouse and human skin, contributing to radiation dermatitis.

research LB1672 Senescent melanocytes in nevus skin stimulate hair growth

August 2023 in “Journal of Investigative Dermatology”

Senescent melanocytes in nevus skin boost hair growth.

research 1445 UVA-induced senescence in human skin ex vivo leads to impaired wound healing

April 2023 in “Journal of Investigative Dermatology”

UVA exposure slows skin wound healing, but α-klotho can reverse this effect.

research 685 Modelling intrinsic and extrinsic cellular senescence in vitro with complex bioengineered human skin constructs

July 2024 in “Journal of Investigative Dermatology”

Bioengineered skin models aging well, useful for studying aging and testing treatments.

research Cellular senescence in skin‐related research: Targeted signaling pathways and naturally occurring therapeutic agents

48 citations , April 2023 in “Aging Cell”

This review discusses cellular senescence in human skin, detailing both beneficial and detrimental effects and suggesting the potential for therapies targeting senescence-related skin disorders, but reports no new clinical results.

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Community Join

5 / 37 results

community Cell senescence-targeted treatment for hair loss, has anyone tried any products/enzymes etc. that use this theory

5 upvotes 1 year ago

DHT causes hair loss by driving cells into senescence, and a polyphenol in black chokeberry may reverse this. A product using this theory is being considered for use alongside finasteride, minoxidil, and microneedling.

community GHK-Cu peptide injections - what is your experience?

13 upvotes 6 months ago

GHK-Cu peptide injections are discussed for hair growth, but users report mixed results and suggest focusing on DHT management first. Some users combine GHK-Cu with treatments like Minoxidil and Dutasteride, but emphasize its benefits for skin rather than hair.

community How ET-02 Works. Also no proof that it's better than Minoxidil. At least for now.

44 upvotes 1 year ago

ET-02, a PAI-1 inhibitor, is not proven to be more effective than Minoxidil for hair loss. Other treatments like finasteride, dutasteride, PP405, and AMP-303 are also discussed, focusing on cellular senescence and oxidative stress.

community Anti-oxidants that reverse hairloss?

86 upvotes 5 years ago

Resveratrol and fisetin, found in red wine and strawberries, may promote hair growth by affecting hair follicle cells. Users discuss various treatments, including natural remedies like saw palmetto and topical applications, with mixed opinions on their effectiveness compared to pharmaceuticals like finasteride.

community Chat is this real? Compound called clascoterone

581 upvotes 9 months ago

Clascoterone shows promising results for hair regrowth in men with androgenetic alopecia, with potential FDA approval by 2026. It acts as a topical androgen receptor blocker, offering a new treatment option with minimal side effects compared to existing treatments like finasteride.

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Learn

1 / 801 results

learn Osteopontin

signaling protein that, when suppressed, may grow hair by reducing inflammation and stem cell loss

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Experts

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Clinics

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