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    Did you mean Senescence-Associated Secretory Phenotype?
    Glossary Senescence-Associated Secretory Phenotype

    condition where aging cells release inflammatory molecules and enzymes

    Senescence-Associated Secretory Phenotype (SASP) refers to a condition where aging or damaged cells release a variety of inflammatory molecules, growth factors, and enzymes into their surroundings. This secretion can contribute to tissue dysfunction, chronic inflammation, and age-related diseases, including hair loss and alopecia, by affecting the local cellular environment and promoting further cellular damage.

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    1. LB1031 Immune Cell-Mediated Amplification of Stem Cell Activation in Hairy Melanocytic Nevus via Osteopontin-CD44 Axis Journal of Investigative Dermatology · 2024 · 1 citations
    2. Cellular senescence in tissue repair: every cloud has a silver lining The International Journal of Developmental Biology · 2018 · 33 citations
    3. Platelet Immune Interactions, Lifespan, and Senescence OBM Geriatrics · 2025 · 1 citations
    4. Oncogenic senescence: a multi-functional perspective Oncotarget · 2017 · 32 citations
    5. Keratinocyte Stem Cells: Role in Aging IntechOpen eBooks · 2022 · 1 citations
    6. Aged Skin Cells Nurture Stem Cells toward Regeneration Journal of Investigative Dermatology · 2023 · 3 citations
    7. Cellular senescence and polycystic ovary syndrome: mechanisms and therapeutic strategies from a new perspective Annals of Medicine · 2025 · 2 citations
    8. Update on Melasma—Part I: Pathogenesis Dermatology and Therapy · 2022 · 10 citations
    9. Immunosenescence and inflammaging in Parkinson’s disease: mechanisms and therapeutic prospects Frontiers in Immunology · 2026
    10. Oxidative Stress–Associated Senescence in Dermal Papilla Cells of Men with Androgenetic Alopecia Journal of Investigative Dermatology · 2015 · 93 citations
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