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Did you mean Senescence-Associated Secretory Phenotype?

Glossary Senescence-Associated Secretory Phenotype

condition where aging cells release inflammatory molecules and enzymes

Senescence-Associated Secretory Phenotype (SASP) refers to a condition where aging or damaged cells release a variety of inflammatory molecules, growth factors, and enzymes into their surroundings. This secretion can contribute to tissue dysfunction, chronic inflammation, and age-related diseases, including hair loss and alopecia, by affecting the local cellular environment and promoting further cellular damage.

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Research

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research LB1031 Immune Cell-Mediated Amplification of Stem Cell Activation in Hairy Melanocytic Nevus via Osteopontin-CD44 Axis

1 citations , July 2024 in “Journal of Investigative Dermatology”

Immune cells boost stem cell activity in hairy moles, causing more hair growth.

research Cellular senescence in tissue repair: every cloud has a silver lining

33 citations , January 2018 in “The International Journal of Developmental Biology”

This review discusses the dual role of cellular senescence in ageing and tissue repair and suggests potential therapeutic applications, with no new experimental results reported.

research Oncogenic senescence: a multi-functional perspective

32 citations , February 2017 in “Oncotarget”

This workshop review discusses the dual role of cellular senescence in cancer, highlighting both its anticancer effects and pro-tumorigenic potential, while reporting no new research results.

research Platelet Immune Interactions, Lifespan, and Senescence

1 citations , January 2025 in “OBM Geriatrics”

This study highlights the role of platelets in immune interactions and severe adenovirus infection, noting that activated platelets have a shorter lifespan. Results suggest potential for developing therapies targeting platelet senescence and immunologic mechanisms.

research Keratinocyte Stem Cells: Role in Aging

1 citations , March 2022 in “IntechOpen eBooks”

This article reviews the functions and locations of skin stem cells and their role in regeneration and differentiation, relating age-associated skin changes to decreased stem cell functionality; it reports no new experimental findings.

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community Everything you ever wanted to know about Pelage Pharma's PP405: how it works and what to expect

126 upvotes 3 months ago

PP405 may encourage earlier hair growth and slightly increase visible hair count but does not reverse hair follicle miniaturization in male pattern baldness. It does not address damage to the dermal papilla or broken Wnt signaling.

community What if DHT is not the vilan.

13 upvotes 5 years ago

Hair loss may be influenced more by inflammation, microbiome imbalances, and gut health than DHT. Treatments discussed include minoxidil, finasteride, RU58841, fecal microbiota transplants, and JAK inhibitors.

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learn Osteopontin

signaling protein that, when suppressed, may grow hair by reducing inflammation and stem cell loss

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