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    Did you mean Senescence-Associated Secretory Phenotype?
    Glossary Senescence-Associated Secretory Phenotype

    condition where aging cells release inflammatory molecules and enzymes

    Senescence-Associated Secretory Phenotype (SASP) refers to a condition where aging or damaged cells release a variety of inflammatory molecules, growth factors, and enzymes into their surroundings. This secretion can contribute to tissue dysfunction, chronic inflammation, and age-related diseases, including hair loss and alopecia, by affecting the local cellular environment and promoting further cellular damage.

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    Research 30 of 1000+

    1. LB1031 Immune Cell-Mediated Amplification of Stem Cell Activation in Hairy Melanocytic Nevus via Osteopontin-CD44 Axis Journal of Investigative Dermatology · 2024 · 1 citations
    2. Cellular senescence in tissue repair: every cloud has a silver lining The International Journal of Developmental Biology · 2018 · 33 citations
    3. Platelet Immune Interactions, Lifespan, and Senescence OBM Geriatrics · 2025 · 1 citations
    4. Oncogenic senescence: a multi-functional perspective Oncotarget · 2017 · 32 citations
    5. Keratinocyte Stem Cells: Role in Aging IntechOpen eBooks · 2022 · 1 citations
    6. Aged Skin Cells Nurture Stem Cells toward Regeneration Journal of Investigative Dermatology · 2023 · 3 citations
    7. Cellular senescence and polycystic ovary syndrome: mechanisms and therapeutic strategies from a new perspective Annals of Medicine · 2025 · 2 citations
    8. Update on Melasma—Part I: Pathogenesis Dermatology and Therapy · 2022 · 10 citations
    9. Immunosenescence and inflammaging in Parkinson’s disease: mechanisms and therapeutic prospects Frontiers in Immunology · 2026
    10. Oxidative Stress–Associated Senescence in Dermal Papilla Cells of Men with Androgenetic Alopecia Journal of Investigative Dermatology · 2015 · 93 citations
    11. Age-associated inflammation connects RAS-induced senescence to stem cell dysfunction and epidermal malignancy Cell death and differentiation · 2015 · 56 citations
    12. Exosomes as Emerging Therapeutics in Aesthetic and Regenerative Medicine: A Scoping Review Journal of Regenerative Medicine and Biology Research · 2026
    13. 559 Induction of tissue-specific premature stem cell aging promotes senescence-like phenotypes in remote multiple organs Journal of Investigative Dermatology · 2022
    14. Premature Senescence of Balding Dermal Papilla Cells In Vitro Is Associated with p16INK4a Expression Journal of Investigative Dermatology · 2007 · 141 citations
    15. Intermediate Hair Follicles from Patients with Female Pattern Hair Loss Are Associated with Nutrient Insufficiency and a Quiescent Metabolic Phenotype Nutrients · 2022
    16. Enterococcus faecium secreted the NlpC/P60 family protein to enhance host immunity and indirectly increases Akkermansia muciniphila for slowing aging Frontiers in Microbiology · 2026
    17. 1447 Anti-senescence effect of extracellular vesicle from hyaluronic acid primed induced mesenchymal stem cells on aged human dermal fibroblast Journal of Investigative Dermatology · 2023
    18. Protective Effect of Iris germanica L. Rhizome-Derived Exosome against Oxidative-Stress-Induced Cellular Senescence in Human Epidermal Keratinocytes Applied sciences · 2023
    19. Cyanidin 3-O-arabinoside suppresses DHT-induced dermal papilla cell senescence by modulating p38-dependent ER-mitochondria contacts Journal of Biomedical Science · 2022 · 14 citations
    20. Aging and Immortality: Quasi-Programmed Senescence and Its Pharmacologic Inhibition Cell Cycle · 2006 · 295 citations
    21. Dermal papilla cells and melanocytes response to physiological oxygen levels depends on their interactions Cell Proliferation · 2021 · 7 citations
    22. Flavonoid 4,4′-dimethoxychalcone selectively eliminates senescent cells via activating ferritinophagy Redox biology · 2023
    23. The systemic wrinkled skin phenotype involves aberrant expression and variation of genes related to the oxidative stress and extracellular matrix in Xiang pigs BMC Genomics · 2025
    24. 1348 Changes in the aging dermal hair follicle environment in female scalp 2018
    25. Oxidative stress in ageing of hair International Journal of Trichology · 2009 · 126 citations
    26. Skin aging: mechanisms, evaluation, and rejuvenation The EMBO Journal · 2026
    27. Restoration of hair follicle inductive properties by depletion of senescent cells Aging Cell · 2024
    28. The Dual Nature of Cellular Senescence: From Aging Signature to Regenerative Catalyst Research · 2025
    29. Cellular Senescence and Aging in Myotonic Dystrophy International Journal of Molecular Sciences · 2022 · 4 citations
    30. Radiation Dermatitis: Radiation-Induced Effects on the Structural and Immunological Barrier Function of the Epidermis International journal of molecular sciences · 2024 · 1 citations