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research Hyperandrogenism and menstrual imbalance are the best predictors of metformin response in PCOS patients

9 citations , January 2022 in “Reproductive Biology and Endocrinology”

This study aimed to identify reliable predictors for the effectiveness of metformin therapy in weight loss and reduction of plasma androgen levels in PCOS women, highlighting the unpredictability of response to treatment.

research Impact of systemic hormonal imbalances on sebaceous gland disorders: An in-depth review integrating clinical, endocrine, and therapeutic insights

August 2026 in “Cosmoderma”

This review identifies sebaceous gland disorders as key indicators of hormonal imbalances, detailing how various hormones affect sebaceous function, and emphasizes a multidisciplinary approach to improve diagnosis and management by integrating endocrine, metabolic, and dermatologic insights.

research The Association of Serum Adipokines, Insulin Resistance and Vitamin D Status in Male Patients with Androgenetic Alopecia

February 2023 in “Clinical, Cosmetic and Investigational Dermatology”

This study found that male patients with Androgenetic alopecia have higher serum leptin, lower vitamin D levels, and an altered adiponectin/leptin ratio, which may contribute to the disease's pathogenesis.

Preponderance of Serum and Intra-Hepatic 5α-Dihydrotestosterone in Males with Hepatocellular Carcinoma Despite Low Circulating Androgen Levels

research Preponderance of serum and intra-hepatic 5α-dihydrotestosterone in males with hepatocellular carcinoma despite low circulating androgen levels

8 citations , January 1986 in “Journal of hepatology”

This study suggests that hepatocellular carcinoma in cirrhotic men is associated with altered sex-steroid metabolism, indicated by lower testosterone and 5 alpha-dihydrotestosterone levels compared to cirrhosis alone.

research Formulation and Evaluation of Polyherbal Scalp Scrub

April 2024 in “International journal of innovative science and research technology”

This article describes the use of natural ingredients like aloe vera juice and neem extract in scalp scrubs, highlighting their role in exfoliating the scalp, balancing sebum, and moisturizing the scalp.

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Community Join

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community Attempting to assist people with gyno sides on finasteride

23 upvotes 2 years ago

Finasteride can cause gynecomastia due to hormonal imbalances. Management includes consulting an endocrinologist and using aromatase inhibitors like anastrozole or supplements like DIM and zinc.

community Muted/dull orgasms explanation?

17 upvotes 3 weeks ago

Finasteride and dutasteride can cause muted orgasms and reduced sensation, possibly due to hormonal imbalances like increased estrogen or reduced DHT. Some users report improvement by adjusting dosages or stopping the medication.

community What if DHT is not the vilan.

13 upvotes 5 years ago

Hair loss may be influenced more by inflammation, microbiome imbalances, and gut health than DHT. Treatments discussed include minoxidil, finasteride, RU58841, fecal microbiota transplants, and JAK inhibitors.

community DHT results after 1 year on dutasteride, confused and seeking guidance

in Finasteride/Dutasteride 107 upvotes 1 year ago

The user is experiencing rapid hair loss despite using dutasteride, finasteride, and minoxidil, and is concerned about high estradiol and testosterone levels. They are advised to consult an endocrinologist for potential hormonal imbalances.

community Feeling energyless and think my 2.5mg dut per day might be causing it

in Research/Science 20 upvotes 1 year ago

Taking 2.5mg of dutasteride daily can cause feelings of low energy, ambition, and motivation, likely due to hormonal imbalances. Many users suggest lowering the dose to 0.5mg to alleviate these side effects.

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Learn

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learn Baicapil

Could a daily serum with Baicapil help revive dormant hair follicles before it’s too late? Yes, a daily serum with Baicapil may help revive dormant hair follicles.

learn Bimatoprost

Can a lash-growth serum like bimatoprost actually work for your scalp? Bimatoprost (Latisse) is approved for eyelashes, not the scalp; two Allergan phase 2 trials in men with androgenetic alopecia posted results to ClinicalTrials.gov but were never published in a peer-reviewed journal, so scalp use remains off-label and experimental.

learn Hyaluronic Acid

What’s the difference between using hyaluronic acid as a serum on the scalp versus taking it as a supplement? Hyaluronic acid serum hydrates the scalp surface, while supplements may support overall hair health.

learn Exosomes

Are exosomes applied as a serum, an injection, or combined with other hair treatments? Exosomes are typically injected directly or combined with other hair treatments.

learn Rapamycin

Are there any visible side effects when using rapamycin cream or serum on the scalp? Visible side effects may include skin irritation or redness when using rapamycin on the scalp.

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