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GlossaryS100 Proteins

calcium-binding proteins involved in cell regulation and signaling

S100 Proteins are a family of calcium-binding proteins involved in various intracellular and extracellular functions, such as regulation of protein phosphorylation, enzyme activities, and cell growth and differentiation. They are implicated in several diseases, including cancer, neurodegenerative disorders, and inflammatory conditions, making them significant both in basic biological research and clinical diagnostics.

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Expression of Calcium-Binding S100 Proteins A4 and A6 in Regions of the Epithelial Sac Associated with the Onset of Hair Follicle Regeneration

research Expression of Calcium-Binding S100 Proteins A4 and A6 in Regions of the Epithelial Sac Associated with the Onset of Hair Follicle Regeneration

72 citations , June 2001 in “Journal of Investigative Dermatology”

S100A4 and S100A6 proteins may activate stem cells for hair follicle regeneration and could be potential targets for hair loss treatments.

research Trichohyalin-Like Proteins Have Evolutionarily Conserved Roles in the Morphogenesis of Skin Appendages

68 citations , April 2014 in “Journal of Investigative Dermatology”

Trichohyalin-like proteins are essential for the development of skin structures like hair, nails, and feathers.

research Desmoplastic Melanoma Presenting as Primary Alopecia Neoplastica: A Report of Two Cases

8 citations , June 2016 in “Journal of Cutaneous Pathology”

Two women were diagnosed with a rare melanoma that looked like hair loss but was actually a type of skin cancer.

research Advances in Molecular Pathogenesis of Hidradenitis Suppurativa: Dysregulated Keratins and ECM Signaling

5 citations , February 2022 in “Seminars in cell & developmental biology”

Recent findings suggest that genetic factors, immune system issues, and skin cell defects might contribute to the development of hidradenitis suppurativa.

research Gene Expression of Mouse S100A3, a Cysteine-Rich Calcium-Binding Protein, in Developing Hair Follicle

40 citations , November 1998 in “The journal of investigative dermatology/Journal of investigative dermatology”

S100A3 protein is crucial for hair shaft formation in mice.

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community In my opinion baldness is more prevalent now and it's being ignored..

in Chat 236 upvotes 2 years ago

The conversation is about the prevalence of baldness among young men and the potential factors contributing to it. Specific treatments mentioned include minoxidil and finasteride.

community Creatine is the opposite of minoxidil !

in Research/Science 325 upvotes 2 weeks ago

Creatine may counteract minoxidil's hair growth effects by closing potassium ATP channels, potentially leading to hair loss in predisposed individuals. Despite anecdotal reports, there is no conclusive evidence linking creatine to hair loss.

community What the hell happened in my family genes?

in Chat 116 upvotes 1 year ago

A user is frustrated about early balding despite older male relatives retaining hair into old age. Another user plans to start finasteride soon to address their hair thinning.

community Does creatine really speed up hair loss if you have male pattern baldness?

in Chat 128 upvotes 1 month ago

Creatine is not proven to cause hair loss, but some report increased shedding, especially with male pattern baldness. Finasteride or minoxidil are suggested to counteract potential hair loss while using creatine.

community [22m] Is it time for a transplant?

in Progress Pictures 56 upvotes 3 months ago

A 22-year-old is experiencing aggressive hair loss despite using minoxidil and finasteride and is considering a hair transplant but lacks funds. The discussion includes advice on treatments like dutasteride, microneedling, and lifestyle changes, with mixed opinions on the timing and effectiveness of a transplant at a young age.

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