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    Glossary S100 Proteins

    calcium-binding proteins involved in cell regulation and signaling

    S100 Proteins are a family of calcium-binding proteins involved in various intracellular and extracellular functions, such as regulation of protein phosphorylation, enzyme activities, and cell growth and differentiation. They are implicated in several diseases, including cancer, neurodegenerative disorders, and inflammatory conditions, making them significant both in basic biological research and clinical diagnostics.

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    Research 30 of 434

    1. Expression of Calcium-Binding S100 Proteins A4 and A6 in Regions of the Epithelial Sac Associated with the Onset of Hair Follicle Regeneration Journal of Investigative Dermatology · 2001 · 72 citations
    2. The Roles of S100 Proteins and RAGE in Melanoma InTech eBooks · 2011 · 5 citations
    3. S-100 Protein Immunoreactivity in the Upper Eyelid of the Sheep Ovis aries Journal of Molecular Histology · 2004 · 2 citations
    4. Identification of Trichohyalin-Like 1, an S100 Fused-Type Protein Selectively Expressed in Hair Follicles Journal of Investigative Dermatology · 2011 · 27 citations
    5. Trichohyalin-Like Proteins Have Evolutionarily Conserved Roles in the Morphogenesis of Skin Appendages Journal of Investigative Dermatology · 2014 · 68 citations
    6. S100 signaling in hair follicle biology: emerging mechanistic insights and therapeutic opportunities Journal of Molecular Histology · 2026
    7. Human Trichohyalin Gene Is Clustered with the Genes for Other Epidermal Structural Proteins and Calcium-Binding Proteins at Chromosomal Locus 1q21 1993
    8. Characterization of the cysteine-rich calcium-binding S100A3 protein from human hair cuticles Biochemical and biophysical research communications · 2002 · 17 citations
    9. Isolation and Characterization of Human Repetin, a Member of the Fused Gene Family of the Epidermal Differentiation Complex Journal of Investigative Dermatology · 2005 · 77 citations
    10. Desmoplastic melanoma presenting as primary alopecia neoplastica: a report of two cases Journal of Cutaneous Pathology · 2016 · 8 citations
    11. Human hair follicle biomagnetism: potential biochemical correlates 2015 · 8 citations
    12. Advances in molecular pathogenesis of hidradenitis suppurativa: Dysregulated keratins and ECM signaling Seminars in cell & developmental biology · 2022 · 5 citations
    13. RAGE and Its Ligands in Melanoma InTech eBooks · 2015 · 1 citations
    14. Obtenção e caracterização das células-tronco do folículo piloso de fetos caninos 2016
    15. Experimental study on the compatibility and degradation of human hair keratin bridging for peripheral nerve defects Zhonghua chuangshang guke zazhi · 2005
    16. 0034 Cross-species insights into hair follicle-T cell interactions in discoid lupus erythematosus: A comparison of human, canine and mouse models using spatial transcriptomics Journal of Investigative Dermatology · 2025
    17. Differentiation of nestin-negative human hair follicle outer root sheath cells into neurons in vitro Molecular Medicine Reports · 2017 · 5 citations
    18. Comparative analysis of stemness between dermal papilla cells and human dermalstem/progenitor cells Cellular and Molecular Biology · 2025
    19. An immunohistochemical study of the apocrine type of cutaneous mixed tumors with special reference to their follicular and sebaceous differentiation Journal of Cutaneous Pathology · 1999 · 54 citations
    20. Giant pigmented tumour of the scalp—a diffuse neurofibroma or a congenital naevus showing neurofibromatous changes? Immunohistochemical and electron microscopic studies Histopathology · 1988 · 12 citations
    21. Diffuse neurofibroma of the scalp with alopecia areata as the initial presentation: a case report International Journal of Dermatology and Venereology · 2014
    22. 1322 Molecular profiling of frontal fibrosing alopecia (FFA) reveals TH1 and JAK-STAT up-regulation with no suppression of hair keratins Journal of Investigative Dermatology · 2018 · 2 citations
    23. S100A6 Protein—Expression and Function in Norm and Pathology International Journal of Molecular Sciences · 2023 · 21 citations
    24. Ultrastructural Localization of S100A3, a Cysteine-rich, Calcium Binding Protein, in Human Scalp Hair Shafts Revealed by Rapid-freezing Immunocytochemistry Journal of Histochemistry & Cytochemistry · 1999 · 40 citations
    25. Human Dermal Fibroblasts Demonstrate Positive Immunostaining for Neuron- and Glia- Specific Proteins PLoS ONE · 2015 · 15 citations
    26. Localization of S100A2, S100A4, S100A6, S100A7, and S100P in the human hair follicle. PubMed · 2014 · 9 citations
    27. Gene Expression Profiles of Melanocytes Over-Expressing miR-5110 in Alpaca Current Issues in Molecular Biology · 2026
    28. S100A6: molecular function and biomarker role Biomarker Research · 2023 · 50 citations
    29. Characterization of Mouse Profilaggrin: Evidence for Nuclear Engulfment and Translocation of the Profilaggrin B-Domain during Epidermal Differentiation 2002 · 25 citations
    30. Protein kinase C is a key target for attenuation of Leigh syndrome by rapamycin bioRxiv (Cold Spring Harbor Laboratory) · 2019 · 5 citations