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Research

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research Derivation and validation of the Systemic Lupus International Collaborating Clinics classification criteria for systemic lupus erythematosus

4350 citations , May 2012 in “Arthritis & Rheumatism”

This study found that the new SLICC classification criteria for systemic lupus erythematosus were more sensitive and resulted in fewer misclassifications than the current ACR criteria, although they had lower specificity.

research Standards of Care for the Health of Transsexual, Transgender, and Gender-Nonconforming People, Version 7

2295 citations , August 2012 in “The international journal of transgenderism/International journal of transgenderism”

This publication reviews the World Professional Association for Transgender Health's Standards of Care for supporting transgender and gender nonconforming people, with adjustments needed for diverse global contexts and no new clinical results.

research Endocrine Treatment of Gender-Dysphoric/Gender-Incongruent Persons: An Endocrine Society* Clinical Practice Guideline

2170 citations , September 2017 in “The Journal of Clinical Endocrinology & Metabolism”

This updated guideline from the Endocrine Society highlights the importance of endocrinologists in providing safe and effective hormone regimens for gender-affirming care, especially for adolescents who have entered puberty.

research Polycystic Ovary Syndrome

1947 citations , September 1995 in “New England journal of medicine/The New England journal of medicine”

This article discusses the heterogeneity of polycystic ovary syndrome, its association with insulin resistance, and its implications for long-term health, but reports no new clinical results.

Criteria for Defining Polycystic Ovary Syndrome as a Predominantly Hyperandrogenic Syndrome: An Androgen Excess Society Guideline

research Criteria for Defining Polycystic Ovary Syndrome as a Predominantly Hyperandrogenic Syndrome: An Androgen Excess Society Guideline

1744 citations , August 2006 in “The Journal of Clinical Endocrinology and Metabolism”

This review discusses definitions of polycystic ovary syndrome and reports no new clinical results; the authors support using modified 1990 NIH criteria and acknowledge ongoing evolution as research advances.

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Community Join

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community Sep 15, '26 Monday Mega Thread: ask general questions, share hairline photos, side effects, “Am I balding?”, “What should I do?”, and more

2 upvotes 1 day ago

People are discussing hair loss concerns, including shedding and regrowth, and treatments like minoxidil and finasteride. Users share experiences with these treatments and seek advice on managing hair loss and potential side effects.

community How many guys here experiencing sides from Fin also watch porn regularly?

22 upvotes 1 day ago

Some users attribute erectile dysfunction (ED) to finasteride, but others suggest porn use or other factors might contribute. There are mixed opinions on finasteride's side effects, with some experiencing mental health issues and others defending its use for hair loss.

community What I've learned about shedding after being on Dut + Min for 2yrs

37 upvotes 1 day ago

Shedding is a normal part of hair regrowth when using treatments like Dutasteride and Minoxidil, and it can take up to two years for shedding to stabilize and hair to fully recover. Patience is crucial, as initial shedding doesn't mean the treatment isn't working.

community Serenoa... am I wasting time or is it worth it? Is it true that the hairline doesn't respond to anti-dht?

1 upvotes 2 days ago

The conversation discusses the effectiveness of saw palmetto versus finasteride for hair loss, with the user expressing frustration over not being prescribed finasteride despite worsening hairline issues. The user is currently using minoxidil and 17-alpha-estradiol topically, with saw palmetto added, but is considering seeking a doctor who will prescribe finasteride.

community One month on finasteride shedding. No cause for worry?

1 upvotes 2 days ago

Shedding one month into finasteride treatment is common and can cause anxiety due to visible thinning. The user is concerned about new thin patches appearing.

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Learn

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learn Scalp Micropigmentation

scalp tattoos to mimic the appearance of light stubble

learn SCUBE3

a signaling molecule from dermal papilla cells being actively researched

learn Stemoxydine

chemical from L'Oreal that encourages hair to enter growth phase

learn Saw Palmetto

a natural and far less effective alternative to Finasteride

Does saw palmetto prevent hair loss or only slow down hair loss that's already started? Saw palmetto may slow down hair loss but does not prevent it.

learn Spironolactone

powerful topical and oral anti-androgen used mostly by women

learn Finasteride

Does stopping finasteride mean losing all progress? Here's what really happens. Studies and the drug label report that finasteride's benefit lasts only while it is taken: after stopping, scalp DHT returns to baseline and hair loss resumes over roughly 6 to 12 months. Stopping a prescription drug is a decision to make with the prescriber.

learn Dutasteride

Dutasteride: Why don't some doctors prescribe it if it's stronger than finasteride? Some doctors avoid prescribing dutasteride due to its higher risk of side effects.

learn Baicapil

Struggling with patchy hair loss like alopecia areata? Baicapil might help by reducing inflammation and reactivating growth. There is no published trial of Baicapil in alopecia areata. The anti-inflammatory and hair-density claims come from the ingredient's manufacturer and from laboratory work on its plant extracts, in people with androgenetic-type hair loss rather than autoimmune patchy hair loss.

learn Botox

What’s the science behind Botox injections for androgenetic alopecia? Small published studies and a 2025 meta-analysis report hair-count gains from scalp botulinum toxin injections, but nearly all of them lack control groups, and reviewers of the same literature call the evidence low-quality; the treatment is off-label and not approved for hair loss anywhere.

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