Seeking advice from dut non-responders who used RU
    Update 8/12/2025

    At a glance
    In this question or advice post, the primary subjects mentioned are
    💊 Dutasteride (oral) 0.5mg 2.5 years
    💧 RU58841 (topical)
    the tone is 😞 negative with no regrowth results.

    Other terms

    The conversation discusses hair loss treatments, specifically the use of RU58841 by individuals who did not respond to dutasteride. Users share experiences with maintaining hair using RU58841 and mention trying pyrilutamide and the upcoming availability of pp405.
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      community Don’t Get Too Hyped About PP405. We've Seen This Movie Before.

      in Research/Science  217 upvotes 4 months ago
      PP405 is a new hair loss treatment showing early promise with a 20% hair density increase, but skepticism exists due to past failures of similar treatments like Pyrilutamide, RU58841, and Bimatoprost. Users debate its potential effectiveness, with some hopeful due to Google's involvement, while others urge caution without more evidence.

      community Switch from fin to dut and its worse

      in Finasteride/Dutasteride  6 upvotes 5 months ago
      Switching from finasteride to dutasteride can worsen hair loss for some men due to increased testosterone levels. Topical treatments like RU58841 and Pyrilutamide are suggested to counteract these effects, but individual responses vary.

      community What do you think about pyrilutamide?

      in Product  5 upvotes 9 months ago
      Pyrilutamide is being discussed as a potential hair loss treatment, but opinions are mixed, with some users skeptical about its effectiveness and the company's credibility. Some users report combining pyrilutamide with other treatments like dutasteride and microneedling, noting improvements, while others remain doubtful.

      community How likely do you think it is for PP405 to come out?

      in Research/Science  21 upvotes 4 weeks ago
      PP405 is a potential new hair loss treatment that works through metabolic pathways rather than hormonal ones, with an estimated market release between late 2027 and 2029. Current alternatives to finasteride include minoxidil, pyralutamide, fluridil, and RU58841, with hair transplants also being a viable option.

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