Androgens And Parkinson's Disease: The Role In Humans And In Experiment

    September 2022 in “ Problems of Endocrinology ”
    Aida U. Hamadyanova, К.О. Кузнецов, E. I. Gaifullina … G. O. Gaisina
    Studysummary This review discusses sex differences in Parkinson's disease and highlights that while men are more frequently affected, androgen-modulating treatments have not yet proven effective for PD, though 5α-reductase inhibitors show potential for further study.
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    Research cited in this study 12

    1. Early Antiandrogen Therapy With Dutasteride Reduces Viral Shedding, Inflammatory Responses, and Time-to-Remission in Males With COVID-19: A Randomized, Double-Blind, Placebo-Controlled Interventional Trial Cureus · 2021
    2. 5-Alpha-Reductase Inhibitors Are Associated With Reduced Frequency of COVID-19 Symptoms in Males With Androgenetic Alopecia Journal of The European Academy of Dermatology and Venereology · 2020
    3. Repurposing Existing Drugs for COVID-19: An Endocrinology Perspective BMC Endocrine Disorders · 2020
    4. Physiopathological Role of the Enzymatic Complex 5α-Reductase and 3α/β-Hydroxysteroid Oxidoreductase in the Generation of Progesterone and Testosterone Neuroactive Metabolites Frontiers in Neuroendocrinology · 2020
    5. 5alpha-Reductase Inhibitors Dampen L-DOPA-Induced Dyskinesia via Normalization of Dopamine D1-Receptor Signaling Pathway and D1-D3 Receptor Interaction Neurobiology of Disease · 2018
    6. Effect of the 5α-Reductase Enzyme Inhibitor Dutasteride in the Brain of Intact and Parkinsonian Mice Journal of steroid biochemistry and molecular biology/˜The œJournal of steroid biochemistry and molecular biology · 2017
    7. The 5-Alpha Reductase Inhibitor Finasteride Reduces Dyskinesia in a Rat Model of Parkinson’s Disease Experimental Neurology · 2017
    8. The Neurosteroidogenic Enzyme 5α-Reductase Modulates the Role of D1 Dopamine Receptors in Rat Sensorimotor Gating Psychoneuroendocrinology · 2015
    9. The 5α-Reductase Inhibitor Dutasteride but Not Finasteride Protects Dopamine Neurons in the MPTP Mouse Model of Parkinson’s Disease Neuropharmacology · 2015
    10. Finasteride Attenuates Pathological Gambling in Patients With Parkinson's Disease Journal of Clinical Psychopharmacology · 2012
    11. Steroid 5α-Reductase as a Novel Therapeutic Target for Schizophrenia and Other Neuropsychiatric Disorders Current Pharmaceutical Design · 2011
    12. A New Look at the 5-Alpha-Reductase Inhibitor Finasteride Cns Drug Reviews · 2006

    Related research 2

    1. The Antiandrogens Dermatologic Clinics · 1993
    2. The Antiandrogens: When And How They Should Be Used PubMed · 1993