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    Glossary Wnt antagonist

    substance that blocks Wnt signaling, affecting cell growth

    A Wnt antagonist is a substance that inhibits the Wnt signaling pathway, which is crucial for various biological processes including cell growth, development, and hair follicle formation. By blocking this pathway, Wnt antagonists can affect hair growth and are being studied for their potential in treating conditions like alopecia.

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    1. Androgens modify Wnt agonists/antagonists expression balance in dermal papilla cells preventing hair follicle stem cell differentiation in androgenetic alopecia Molecular and Cellular Endocrinology · 2016 · 47 citations
    2. 195 Androgen action and 3D culture conditions influence dermal papilla cells inductive properties: the role of Wnt agonists/antagonists balance Journal of Investigative Dermatology · 2016
    3. The role of dexamethasone in mediating the contradictory effects of Wnt antagonists SFRP2 and SFRP3 on human hair follicle growth Scientific reports · 2023
    4. THE ROLE OF AGONISTS AND ANTAGONISTS OF THE WNT SIGNALING PATHWAY IN PATIENTS WITH ANDROGENIC ALOPECIA AND ALOPECIA AREATA Медико-фармацевтический журнал "Пульс" · 2021
    5. Bone Morphogenetic Protein Antagonist Noggin Promotes Skin Tumorigenesis via Stimulation of the Wnt and Shh Signaling Pathways American Journal Of Pathology · 2009 · 45 citations
    6. The Androgen Receptor Antagonizes Wnt/β-Catenin Signaling in Epidermal Stem Cells Journal of Investigative Dermatology · 2015 · 46 citations
    7. Mesenchymal Stem Cells Antagonize IFN-Induced Proinflammatory Changes and Growth Inhibition Effects via Wnt/β-Catenin and JAK/STAT Pathway in Human Outer Root Sheath Cells and Hair Follicles International journal of molecular sciences · 2021 · 14 citations
    8. Adipose-Derived Stem Cell Exosomes Antagonize the Inhibitory Effect of Dihydrotestosterone on Hair Follicle Growth by Activating Wnt/β-Catenin Pathway Stem Cells International · 2023
    9. Faculty Opinions recommendation of Bone morphogenetic protein antagonist noggin promotes skin tumorigenesis via stimulation of the Wnt and Shh signaling pathways. Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature · 2009
    10. Targeting Endogenous Wnt Antagonists for Therapy Development in AGA: a Focus on DKKs and sFRPs Stem Cell Reviews and Reports · 2026
    11. Human CD133 <sup>+</sup> Progenitor Cells Promote the Healing of Diabetic Ischemic Ulcers by Paracrine Stimulation of Angiogenesis and Activation of Wnt Signaling Circulation Research · 2009 · 245 citations
    12. Liposomal Packaging Generates Wnt Protein with In Vivo Biological Activity PLOS ONE · 2008 · 75 citations
    13. Involvement of Wnt, Eda and Shh at defined stages of sweat gland development Development · 2014 · 55 citations
    14. Wnt signaling: the good and the bad Acta Biochimica et Biophysica Sinica · 2008 · 48 citations
    15. Suppression of Wnt/β-catenin signaling by EGF receptor is required for hair follicle development Molecular Biology of the Cell · 2018 · 25 citations
    16. 447 Skin-Associated Cartilage Consists of Lipid-Filled Cells That Modify Hair Growth via BMP and WNT Signaling Journal of Investigative Dermatology · 2025
    17. Mycophenolate Antagonizes IFN-γ-Induced Catagen-Like Changes via β-Catenin Activation in Human Dermal Papilla Cells and Hair Follicles International Journal of Molecular Sciences · 2014 · 11 citations
    18. Role of the bone morphogenetic protein signalling in skin carcinogenesis. Effect of transgenic overexpression of BMP antognist Noggin on skin tumour development; molecular mechanisms underlying tumour suppressive role of the BMP signalling in skin. Bradford Scholars (University of Bradford) · 2009
    19. Androgenetic alopecia: combing the hair follicle signaling pathways for new therapeutic targets and more effective treatment options Expert Opinion on Therapeutic Targets · 2019 · 19 citations
    20. Serum Dicckopf-1 Level in Patients of Cicatricial and Non- Cicatricial Alopecia Benha Journal of Applied Sciences · 2022
    21. Decision letter: A multi-scale model for hair follicles reveals heterogeneous domains driving rapid spatiotemporal hair growth patterning 2017
    22. Bone Morphogenetic Protein Signaling Inhibits Hair Follicle Anagen Induction by Restricting Epithelial Stem/Progenitor Cell Activation and Expansion Stem Cells · 2006 · 176 citations
    23. New investigational drugs for androgenetic alopecia Expert Opinion on Investigational Drugs · 2013 · 48 citations
    24. A bald statement - Current approaches to manipulate miniaturisation focus only on promoting hair growth Experimental Dermatology · 2018 · 30 citations
    25. CCN2 modulates hair follicle cycling in mice Molecular Biology of the Cell · 2013 · 21 citations
    26. Gene Expression Profiling of the Intact Dermal Sheath Cup of Human Hair Follicles Acta dermato-venereologica · 2018 · 11 citations
    27. New Treatments for Hair Loss Actas Dermo-Sifiliográficas · 2017 · 7 citations
    28. Advances in hair growth Faculty reviews · 2022 · 1 citations
    29. 845 Dermal lymphatic vessels promote hair follicle growth via the BMP inhibitor Sostdc1 Journal of Investigative Dermatology · 2017
    30. 700 Oncostatin M is upstream of JAK-STAT signaling during the murine hair cycle Journal of Investigative Dermatology · 2016