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Dutasteride treatment in men with mild to moderate COVID-19 reduced viral shedding, inflammation, and recovery time without serious side effects.

Early treatment with certain drug combinations improved COVID-19 outcomes and prevented severe disease in males, including those at higher risk.

Men with male pattern baldness had worse COVID-19 symptoms, but early treatment with certain drugs improved outcomes for all.

Many patients experience long-lasting symptoms like fatigue and pain after COVID-19, regardless of initial disease severity.

The conclusion is that individual differences in COVID-19 severity are influenced by factors like age, sex, race, and genetics, which are important for personalized medicine.

SARS-CoV-2, the virus causing COVID-19, can affect all endocrine organs and systems, altering their function and potentially leading to disorders. Factors like diabetes and obesity increase infection risk and severity. Understanding these effects is key for effective treatment.

The authors maintain that shorter androgen receptor alleles may lead to milder COVID-19 by positively affecting the immune response, not due to changes in testosterone levels or activity.

Men and women get COVID-19 at similar rates, but men tend to get sicker and have a higher risk of dying, while women usually have stronger immune responses and vaccine reactions.

Repurposing existing drugs for COVID-19 shows promise but requires more research to confirm effectiveness.

COVID-19 might affect male fertility, but more research is needed to understand the full impact.

Certain genetic differences may affect how likely someone is to get COVID-19 and how severe it might be.

The letter suggests testosterone replacement therapy might worsen COVID-19 outcomes.

Men, especially older ones with health issues like prostate cancer, may have worse COVID-19 outcomes and could benefit from therapies targeting male hormones.

Men, diabetes, and high inflammation levels lead to higher COVID-19 antibodies.

Mesenchymal stromal cells may help treat severe COVID-19, but more research is needed to confirm their effectiveness.

Dengue virus can infect human hair follicle cells and may cause hair loss.

COVID-19 may worsen with androgens; anti-androgen drugs could help.

Some existing drugs and natural products might work against COVID-19 by targeting the virus's main protease.

Smoking harms the skin, causing early aging and increasing cancer risk, but stopping smoking can improve skin health.

COVID-19 can cause skin issues like rashes and "COVID toes," and people with skin conditions should adjust their treatments if they get the virus.

People with diabetes or obesity should manage their conditions carefully as they have a higher risk of severe COVID-19.

Tissue-resident memory T cells can protect against infections and cancer but may also contribute to autoimmune diseases.

Children generally have milder SARS symptoms than adults, with good outcomes and no deaths reported, but long-term effects are unclear.

Anabolic steroid users may face higher risk of severe COVID-19.

Using systemic drugs as creams for skin conditions shows promise, but more research is needed to confirm their effectiveness and safety.

Possible link between androgens and COVID-19 severity; more research needed.

Removing anthrax toxin receptor 1 in pigs prevents Senecavirus A infection and causes a rare disease similar to GAPO syndrome.

HIV-infected men who have sex with men are at higher risk for aggressive syphilis, but treatment and tests are effective.

Higher dihydrotestosterone may be linked to more inflammation in COVID-19 patients with low testosterone.

Early detection and skin biopsies are crucial for treating skin cancer and diagnosing various skin conditions.