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    Glossary Type I Keratin

    Type I keratin is a fibrous protein that is a key structural component of hair, skin, and nails. It is classified as an acidic keratin and is primarily found in the hard tissues of the body, contributing to the strength and resilience of hair strands. In the context of hair loss, understanding type I keratin is relevant as it plays a crucial role in hair follicle health and integrity; any disruption in its production or structure can lead to weakened hair and increased susceptibility to hair loss. Distinguishing characteristics of type I keratin include its high tensile strength and its ability to form complex structures with other keratins, particularly type II keratins, to create the overall architecture of hair.

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    1. Sequence Data and Chromosomal Localization of Human Type I and Type II Hair Keratin Genes Experimental Cell Research · 1995 · 52 citations
    2. A family of type I keratin genes and the homeobox-2 gene complex are closely linked to the rex locus on mouse chromosome 11 Genomics · 1989 · 49 citations
    3. A gene for monilethrix is closely linked to the type II keratin gene cluster at 12q13 Human Molecular Genetics · 1995 · 54 citations
    4. Mapping of monilethrix to the type II keratin gene cluster at chromosome 12q13 in three new families, including one with variable expressivity British Journal of Dermatology · 1997 · 21 citations
    5. Characterization of a Cluster of Human High/Ultrahigh Sulfur Keratin-associated Protein Genes Embedded in the Type I Keratin Gene Domain on Chromosome 17q12-21 2001 · 98 citations
    6. A group of type I keratin genes on human chromosome 17: characterization and expression. Molecular and Cellular Biology · 1988 · 141 citations
    7. Characterization of a 190-Kilobase Pair Domain of Human Type I Hair Keratin Genes 1998 · 74 citations
    8. The human type I keratin gene family: Characterization of new hair follicle specific members and evaluation of the chromosome 17q21.2 gene domain Differentiation · 2004 · 70 citations
    9. A mutation in the hair matrix and cuticle keratin KRTHB5 gene causes ectodermal dysplasia of hair and nail type Journal of Medical Genetics · 2006 · 60 citations
    10. A Group of Type I Keratin Genes on Human Chromosome 17: Characterization and Expression Molecular and Cellular Biology · 1988 · 38 citations
    11. A Splice Site Mutation in the Gene of the Human Type I Hair Keratin hHa1 Results in the Expression of a Tailless Keratin Isoform Journal of Biological Chemistry · 1997 · 28 citations
    12. Mutations in the helix termination motif of mouse type I IRS keratin genes impair the assembly of keratin intermediate filament Genomics · 2007 · 27 citations
    13. The Human Type II Keratin Gene Cluster on Chromosome 12q13.13: Final Count or Hidden Secrets? 2005 · 9 citations
    14. Differential expression of type I IRS keratin genes in three breeds of sheep Zhongguo shouyi xuebao · 2012
    15. Complete sequence of a hair-like intermediate filament type II keratin gene DNA sequence · 1993 · 15 citations
    16. 301 Whole exome sequencing in AA patients identifies a hotspot mutation in the type II hair keratin gene, KRT82 2020
    17. Mutation analysis of type II hair keratin gene in a pedigree with monilethrix Chinese Journal of Dermatology · 2010
    18. Detection of Type IIHair Keratin Gene in a Family with Monilethrix Chinese Journal of Dermatovenereology of Integrated Traditional and Western Medicine · 2010
    19. Characterization of a 300 kbp Region of Human DNA Containing the Type II Hair Keratin Gene Domain Journal of Investigative Dermatology · 2000 · 77 citations
    20. Hair follicle differentiation: expression, structure and evolutionary conservation of the hair type II keratin intermediate filament gene family Development · 1992 · 65 citations
    21. Androgen Regulation of the Human Hair Follicle: The Type I Hair Keratin hHa7 Is a Direct Target Gene in Trichocytes Journal of Investigative Dermatology · 2004 · 49 citations
    22. A novel human type I hair keratin gene: evidence for two keratin hHa3 isoforms Molecular Biology Reports · 1995 · 21 citations
    23. A mutation in the type II hair keratin KRT86 gene in a Han family with monilethrix 2011 · 3 citations
    24. A mutation in the type II hair keratin KRT86 gene in a Han family with monilethrix 生物医学研究杂志:英文版 · 2011 · 3 citations
    25. Sequence of a Cashmere goat type I hair keratin gene and its expression in skin Frontiers of Agriculture in China · 2008 · 3 citations
    26. Mutation detection of type II hair cortex keratin gene KRT86 in a Chinese Han family with congenital monilethrix Chinese Medical Journal · 2013 · 4 citations
    27. A Novel Mouse Type I Intermediate Filament Gene, Keratin 17n (K17n), Exhibits Preferred Expression in Nail Tissue Journal of Investigative Dermatology · 2004 · 31 citations
    28. A Unique Type I Keratin Intermediate Filament Gene Family is Abundantly Expressed in the Inner Root Sheaths of Sheep and Human Hair Follicles Journal of Investigative Dermatology · 2001 · 41 citations
    29. Hair-Specific Keratins: Characterization and Expression of a Mouse Type I Keratin Gene Journal of Investigative Dermatology · 1991 · 27 citations
    30. Characterization of New Members of the Human Type II Keratin Gene Family and a General Evaluation of the Keratin Gene Domain on Chromosome 12q13.13 Journal of Investigative Dermatology · 2005 · 92 citations