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Discovery of 7-Methoxy-6-[4-(4-Methyl-1,3-Thiazol-2-yl)-1H-Imidazol-5-yl]-1,3-Benzothiazole (TASP0382088): A Potent and Selective Transforming Growth Factor-β Type I Receptor Inhibitor as a Topical Drug for Alopecia

research Discovery of 7-Methoxy-6-[4-(4-Methyl-1,3-Thiazol-2-yl)-1H-Imidazol-5-yl]-1,3-Benzothiazole (TASP0382088): A Potent and Selective Transforming Growth Factor-β Type I Receptor Inhibitor as a Topical Drug for Alopecia

6 citations, January 2013 in “Chemical & pharmaceutical bulletin/Chemical and pharmaceutical bulletin”

A new compound shows promise as a topical treatment for hair loss.

Synthesis and In Vitro Study of 17β-[N-Ureylene-N,N′-Disubstituted]-4-Methyl-4-Aza-5α-Androstan-3-Ones as Selective Inhibitors of Type I 5α-Reductase

research Synthesis and In Vitro Study of 17β-[N-Ureylene-N,N′-Disubstituted]-4-Methyl-4-Aza-5α-Androstan-3-Ones as Selective Inhibitors of Type I 5α-Reductase

5 citations, February 1997 in “Bioorganic & Medicinal Chemistry”

New compounds were made that effectively block a specific enzyme related to androgen conditions.

research Connective Tissue Sheath of Hair Follicle Is a Major Source of Dermal Type I Procollagen in Human Scalp

4 citations, September 2012 in “Journal of dermatological science”

The hair follicle's connective tissue is a key source of a certain collagen in human scalp skin.

research Inhibitory Effect of Angiogenin on the Expression of Type I Collagen and Fibronectin in Dermal Papilla Cells from Androgenetic Alopecia Areas

September 2018 in “Chinese Journal of Dermatology”

Angiogenin may help treat hair loss by reducing certain proteins in hair cells.

research PNU 157706, A Novel Dual Type I and II 5α-Reductase Inhibitor

42 citations, February 1998 in “The Journal of Steroid Biochemistry and Molecular Biology”

PNU 157706 is a more effective treatment than finasteride for conditions caused by DHT, like enlarged prostate and hair loss.

research Comprehensive Transcriptome Profiling of Balding and Non-Balding Scalps in Trichorhinophalangeal Syndrome Type I Patient

9 citations, January 2017 in “Annals of Dermatology”

The study found genetic differences related to hair development that may explain hair loss in a patient with Trichorhinophalangeal syndrome type I.

research A Randomized Pilot Study to Compare Hair Follicle Cell Suspensions Prepared Using Trypsin Alone Versus Trypsin in Combination with Collagenase Type I for Transplantation in Vitiligo

5 citations, July 2019 in “Clinical and experimental dermatology”

Adding collagenase to trypsin improves cell yield and repigmentation in vitiligo treatment.

research Expression of Collagen Type I, Skin Fibroblasts, and Macrophages After 1550 nm Erbium Glass Fractional Laser in Androgenic Alopecia

January 2020

The 1550 nm fractional Er:Glass laser improved hair regrowth in patients with androgenic alopecia, but didn't significantly change collagen type I, skin fibroblasts, or macrophages. More research is needed for optimal results.

research Topical MK-386, an Inhibitor of 5α-Reductase Type I, Suppresses Sebum DHT

February 1996 in “Clinical Pharmacology & Therapeutics”

MK-386 reduces sebum DHT levels.

research Rare Case of Leydig Cell Tumor with Type I Diabetes Mellitus Causing Female Pattern Hair Loss

August 2019 in “Journal of Dermatology”

Woman with diabetes had hair loss due to rare ovarian tumor; surgery improved hair growth.

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