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    Glossary Steroid 5 Alpha-Reductase 1

    converts testosterone into a more potent androgen, dihydrotestosterone

    Steroid 5 Alpha-Reductase 1 (SRD5A1) is an enzyme that converts testosterone into dihydrotestosterone (DHT), a more potent androgen hormone. This enzyme plays a significant role in the development of male characteristics and is also implicated in conditions like androgenic alopecia (male pattern baldness) and benign prostatic hyperplasia.

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    1. LY191704: a selective, nonsteroidal inhibitor of human steroid 5 alpha-reductase type 1. Proceedings of the National Academy of Sciences of the United States of America · 1993 · 53 citations
    2. Discovery of Natural Steroid 5 Alpha-Reductase Inhibitors Assay and Drug Development Technologies · 2018 · 11 citations
    3. Cloning, computational analysis and expression profiling of steroid 5 alpha-reductase 1 (SRD5A1) gene during reproductive phases and ovatide stimulation in endangered catfish, Clarias magur Scientific reports · 2023
    4. Sexual dimorphism of growth plate prehypertrophic and hypertrophic chondrocytes in response to testosterone requires metabolism to dihydrotestosterone (DHT) by steroid 5‐alpha reductase type 1 Journal of Cellular Biochemistry · 2005 · 27 citations
    5. Intraethnic variation in steroid-5-alpha-reductase polymorphisms in prostate cancer patients: a potential factor implicated in 5-alpha-reductase inhibitor treatment 2015 · 4 citations
    6. Selected variants of the steroid-5-alpha-reductase isoforms SRD5A1 and SRD5A2 and the sex steroid hormone receptors ESR1, ESR2 and PGR: No association with female pattern hair loss identified Experimental Dermatology · 2012 · 18 citations
    7. Anti-androgenic curcumin analogues as steroid 5-alpha reductase inhibitors Medicinal Chemistry Research · 2017 · 12 citations
    8. Effects on Steroid 5-Alpha Reductase Gene Expression of Thai Rice Bran Extracts and Molecular Dynamics Study on SRD5A2 Biology · 2021 · 14 citations
    9. Expression and Activity Assay of Human Steroid 5 Alpha-Reductase Type II in CHO Cells Pharmaceutical biotechnology · 2004
    10. A Role for Steroid 5 alpha-reductase 1 in Vascular Remodelling During Endometrial Decidualisation bioRxiv (Cold Spring Harbor Laboratory) · 2022
    11. A role for steroid 5 alpha-reductase 1 in vascular remodeling during endometrial decidualization Frontiers in endocrinology · 2022 · 4 citations
    12. Inhibition of steroid 5 alpha-reductase with finasteride: sleep-related erections, potency, and libido in healthy men. The Journal of Clinical Endocrinology and Metabolism · 1995 · 15 citations
    13. Nonsteroidal inhibitors of human type I steroid 5-.alpha.-reductase Journal of Medicinal Chemistry · 1993 · 89 citations
    14. Screen steroid 5 alpha-reductase inhibitors in vitro by high performance liquid chromatography Fuzhou daxue xuebao. Ziran kexue ban · 2005
    15. Inhibition of steroid 5 alpha-reductase with finasteride: sleep-related erections, potency, and libido in healthy men The Journal of Clinical Endocrinology and Metabolism · 1995 · 14 citations
    16. Crystal structure of Steroid 5-alpha-reductase 2 in complex with Finasteride 2020
    17. Hair growth effects of oral administration of finasteride, a steroid 5 alpha-reductase inhibitor, alone and in combination with topical minoxidil in the balding stumptail macaque. The Journal of Clinical Endocrinology and Metabolism · 1992 · 34 citations
    18. 5 alpha-reductase inhibition by a new synthetic steroid (PM-9) in cultures of Penicillium crustosum. PubMed · 2002 · 1 citations
    19. Sex dependent influence of a functional polymorphism in steroid 5‐α‐reductase type 2 (<i>SRD5A2</i>) on post‐traumatic stress symptoms American Journal of Medical Genetics Part B Neuropsychiatric Genetics · 2013 · 35 citations
    20. Geographic Influence and Metabolomics-Driven Discovery of 5-Alpha Reductase Inhibitors in Tectona grandis L.f. (Teak) Leaves Molecules · 2025
    21. The 5 Alpha-Reductase Isozyme Family: A Review of Basic Biology and Their Role in Human Diseases Advances in Urology · 2011 · 218 citations
    22. Synthesis of Spiro[cyclohexane-1,2?-[2H]indene] derivatives as inhibitors of steroid 5?-reductase Helvetica Chimica Acta · 1995 · 8 citations
    23. Synthesis, Biological Evaluation and Molecular Docking of Avicequinone C Analogues as Potential Steroid 5α-Reductase Inhibitors Chemical & Pharmaceutical Bulletin · 2017 · 13 citations
    24. Synthesis and Biological Evaluation of 4-(4-(Alkyl-and Phenylaminocarbonyl)benzoyl)benzoic Acid Derivatives as Non-steroidal Inhibitors of Steroid 5α-Reductase Isozymes 1 and 2 Archiv Der Pharmazie · 2002 · 8 citations
    25. Comprehensive Evaluation of <i>Tectona grandis</i> L.f.: Integrated <i>In Vitro</i> and <i>In Silico</i> Analysis of Steroid 5α-Reductase Inhibition and Anti-Inflammatory Properties ACS Omega · 2025
    26. GhDET2, a steroid 5α‐reductase, plays an important role in cotton fiber cell initiation and elongation The Plant Journal · 2007 · 193 citations
    27. Synthesis of phenanthridin-3-one derivatives: Non-steroidal inhibitors of steroid 5-α-reductase Tetrahedron Letters · 1995 · 20 citations
    28. Steroid 5α-reductase 2 deficiency leads to reduced dominance-related and impulse-control behaviors Psychoneuroendocrinology · 2018 · 14 citations
    29. Steroid 5α-reductase inhibition by polymethoxyflavones 한국응용생명화학회지 · 2013 · 6 citations
    30. Fast Motions in 5 Alpha Reductase and Its Impact on Enzyme Kinetics ACS Catalysis · 2026