21 citations
,
September 2016 in “Breast” This study investigated scalp cooling in breast cancer patients undergoing chemotherapy, finding that those who reached a lower mean scalp skin temperature of 18 °C during cooling were less likely to require a wig or head covering compared to those with higher temperatures.
62 citations
,
February 2011 in “Expert review of dermatology” This review discusses the incidence, reversibility, and impact of chemotherapy-induced alopecia and concludes that scalp cooling is the most effective prevention method in most cases, though some questions remain.
7 citations
,
December 2015 in “Journal of thermal biology” This study used numerical models to explore the cooling power required by different scalp cooling devices to prevent chemotherapy-induced hair loss, finding that coolant temperature significantly influences scalp tissue temperatures.
In this study, women in their 40s with hair loss showed significant improvements in hair properties such as pore density and hair thickness when treated with a caffeine-based scalp ampoule and Microneedle Therapy System, compared to a caffeine-free control.
December 2022 in “Frontiers in Microbiology” This study found that individuals with androgenetic alopecia had higher scalp microbiome diversity and more complex scalp-gut microbiome networks than those without, suggesting a link between skin-gut microorganisms and hair loss development.
1 citations
,
January 2013 in “Journal of S C C J” This study suggests that scalp massage may reduce stress, as indicated by decreased salivary cortisol and increased secretory immunoglobulin A, and improve comfort by reducing physical fatigue and negative emotions.
November 2023 in “Indian journal of surgery” This study found that platelet-rich gel is a simple and effective non-surgical method for healing exposed skull injuries, resulting in complete healing with minimal scars and sparse hair growth in all patients.
January 2006 in “东华大学学报:英文版” This study found that treating yak hair fibers with low-temperature plasma and microwaves weakened the scale structure and significantly improved dyeability.
2 citations
,
January 2009 in “The Journal of Korean Medicine Ophthalmology and Otolaryngology and Dermatology” This analysis of clinical records found that the highest incidence of alopecia patients visiting a Korean medicine clinic were aged 20-30, with androgenic alopecia being the most common type.
This study found that low-temperature rendering of black beans, peony, and green tea extracts retains higher antioxidant properties and effectively supports scalp health by strengthening follicles and moisturizing the scalp.
6 citations
,
September 2010 in “Archives of Dermatology” This case study suggests that thermography could objectively assess pain severity in herpes zoster patients by correlating thermal images with reported pain intensity.
30 citations
,
April 2017 in “Journal of structural biology” This study suggests that human keratin fiber matrix has a well-defined nano-scale grainy structure rather than being amorphous, with grain size influenced by chemical treatments, temperature, humidity, and follicle-level factors.
53 citations
,
June 1982 in “The BMJ” Cooling the scalp below 22°C before and during chemotherapy can help prevent hair loss.
17 citations
,
June 2020 in “Anais brasileiros de dermatologia/Anais Brasileiros de Dermatologia” This paper provides an overview of scalp cooling as an effective and safe intervention for preventing chemotherapy-induced alopecia, addressing its impact on cancer patients and survivors.
1 citations
,
June 2023 in “Sciential - McMaster Undergraduate Science Journal” This paper reviews scalp cooling as an effective method for preventing chemotherapy-induced alopecia, highlighting recent trials that demonstrate its ability to preserve and regrow hair, thus improving patient well-being.
1 citations
,
April 2022 in “Journal of The American Academy of Dermatology” This study found that decreased pressure sensitivity and 2-point discrimination at the scalp's vertex were significantly associated with androgenetic alopecia in men.
September 2023 in “Jurnal MIPA (edisi elektronik)” This study formulated and evaluated the physical stability of hair tonic preparations using lime extract (Citrus aurantifolia) at varying concentrations. The researchers found that the tonics exhibited good physical stability, as indicated by meeting Indonesian National Standards, even after undergoing temperature cycling tests.
January 2021 in “Zenodo (CERN European Organization for Nuclear Research)” This study found that coated microneedles promoted drug release effectively, comparable to marketed minoxidil solutions, with stable performance over 30 days at high temperatures.
This study developed a hat-shaped device with wearable sensors to estimate scalp moisture content using machine learning, demonstrating that it can provide accurate measurements comparable to professional scalp analyzers without the need for high-cost equipment.
5 citations
,
October 2016 in “Anais Brasileiros de Dermatologia” This report describes a rare case of leprosy involving the scalp, a location not typically conducive to Mycobacterium leprae infection, and adds to existing literature without presenting new experimental findings.
2 citations
,
January 1997 in “Leprosy Review” This case report documents a rare instance of a female Indian patient with borderline-lepromatous leprosy experiencing generalized leprous alopecia of the scalp and lepromatous lymphadenitis of the suboccipital node.
August 2026 in “Indonesian Journal of Global Health Research” This study reports that scalp cooling is 40%-90% effective in preventing chemotherapy-induced hair loss among breast cancer patients, particularly with taxane-based treatments, though some exhibited discontinuation due to mild side effects.
September 2024 in “Journal of Cosmetic Dermatology” Cold gel compresses are the best for pain relief during scalp microneedling.
13 citations
,
October 2015 in “Journal of the European Academy of Dermatology and Venereology” The document concludes that early recognition and appropriate treatment of red scalp, red ear, and red scrotum syndromes can lead to remission.
September 2017 in “Journal of Investigative Dermatology” This study found that infrared thermography might be a useful non-invasive tool to help diagnose frontal fibrosing alopecia by identifying active phases of the disease.
January 2005 in “Chinese Journal of Medical Aesthetics and Cosmetology” This study found that hair autotransplantation, with techniques such as keeping fat around hair follicles and sheath-insert transplantation, can result in a natural appearance and 33% higher density compared to traditional methods.
3 citations
,
January 2011 in “Wspolczesna Onkologia-Contemporary Oncology” Scalp hypothermia can prevent chemotherapy-induced hair loss but is not suitable for all patients, and more research is needed to improve prevention methods.
December 2025 in “Zenodo (CERN European Organization for Nuclear Research)” This study offers a new perspective on androgenetic alopecia, suggesting that hair loss at the vertex and frontal scalp results from mechanical and thermodynamic stress, alongside androgen activity, and proposes that reducing mechanical tension and improving local microcirculation could complement traditional treatments.
This study evaluated various herbal blends of powdered leaves, including Henna and Indigo, for their coloring and sensitivity reactions, finding Henna and Indigo to be effective natural colorants for achieving a reddish-brown hair color with better retention than marketed herbal hair dyes.
November 2021 in “Austin therapeutics” This review discusses the impact of chemotherapy-induced alopecia on cancer patients, the current use of scalp cooling for prevention, and potential future treatments, but presents no new clinical results.