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Safflower has been used in traditional medicine for centuries and shows promise in treating heart, brain, and inflammatory conditions, but more research is needed to ensure its safety.

Using anabolic androgenic steroids can cause serious, lasting health problems in many parts of the body.

Acitretin is effective for severe psoriasis and can be used long-term due to no immunosuppression, but must be carefully monitored for side effects and is not for pregnant women.

Genetic variants linked to ten skin diseases were found, showing both immune and non-immune factors play a role.

Probe detects finasteride with high selectivity and low detection limit.

Interferons are effective for some skin conditions and cancers, but can have side effects and need more research for optimal use.

The combination of cyclosporine and PUVA might help treat severe alopecia areata.

Most treatments for spondyloarthritis are safe, but monitoring and careful selection based on patient risks are important.

The document concludes that inhalation of oxygen and sumatriptan injections are primary for cluster headaches, indomethacin for paroxysmal hemicrania, and lidocaine and lamotrigine for SUNCT, but SUNCT often resists treatment.

Androgen excess disorders in women were effectively treated with spironolactone, estrogen, and dexamethasone.

Metformin helps regulate menstrual cycles, induce ovulation, and improve pregnancy outcomes in women with PCOS.

The review says skin conditions with sterile pustules need more research for better treatments.

The rapid corticotropin test is a quick and simple way to diagnose adrenal insufficiency.

Sorafenib can cause facial acne-like eruptions, which improve after reducing the dose or stopping the drug.

Lupus treatment requires a combination of drugs and therapies, with research needed for new options.

An 11-month-old boy with Menkes disease had severe brain shrinkage and abnormal blood vessels, and didn't respond well to treatment.

Immune checkpoint inhibitors can cause skin issues but are linked to better cancer outcomes.

Rivaroxaban can cause liver injury, allergic reactions, blood vessel inflammation, and hair loss, but these side effects are rare.

Targeting specific miRNAs may help treat hair follicle issues caused by hydrogen peroxide.

Retinoids can prevent skin cancer in high-risk people but have side effects and require more research on dosing and effectiveness.

Some treatments can help hair regrowth in alopecia areata, but none offer a cure, and effectiveness varies.

The document concludes that DAB389-IL2 is promising for treating refractory cutaneous T-cell lymphoma, but more research is needed on its effectiveness and side effect management.

New drugs targeting DNA enzymes show promise for cancer treatment but have side effects like immune system suppression and hair loss.

COVID-19 may affect male fertility and women might have better outcomes due to hormonal and immune differences.

The skin acts like an endocrine organ, making hormones that affect skin diseases and respond to stress.

Spironolactone is a low-cost, effective, and generally safe treatment for various skin conditions related to hormones.

Radiotherapy was effective for treating a large scalp plaque of Bowen's disease when other treatments failed.

Transdermal testosterone can improve sexual desire in postmenopausal women but lacks long-term safety data and is not FDA-approved for this use.

Exemestane is effective and safe for treating certain breast cancers, with mild side effects, but needs more research on long-term effects.

Women with PCOS have lower amylin levels, which are not related to their body weight.