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    Glossary Protein Kinase A

    enzyme activated by cAMP that regulates various cellular processes

    Protein Kinase A (PKA), also known as cAMP-dependent protein kinase, is an enzyme that plays a crucial role in regulating various cellular processes. It is activated by cyclic AMP (cAMP) and is involved in pathways that control cell growth, metabolism, and gene expression. PKA works by adding phosphate groups to specific proteins, which can alter their activity and function.

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    1. Protein Kinase Cε, which Sensitizes Skin to Sun's UV Radiation–Induced Cutaneous Damage and Development of Squamous Cell Carcinomas, Associates with Stat3 Cancer Research · 2007 · 76 citations
    2. Protein kinase Akt2/PKBβ is involved in blastomere proliferation of preimplantation mouse embryos Journal of Cellular Physiology · 2019 · 7 citations
    3. Protein Kinase C δ Overexpressing Transgenic Mice Are Resistant to Chemically but not to UV Radiation–Induced Development of Squamous Cell Carcinomas: A Possible Link to Specific Cytokines and Cyclooxygenase-2 Cancer Research · 2006 · 35 citations
    4. Activation of Cutaneous Protein Kinase Cα Induces Keratinocyte Apoptosis and Intraepidermal Inflammation by Independent Signaling Pathways The Journal of Immunology · 2003 · 74 citations
    5. Protein Kinase C Downregulation upon Rapamycin Treatment Attenuates Neuroinflammation and Mitochondrial Disease Innovation in aging · 2020
    6. 2,3,7,8‐Tetrachlorodibenzo‐<i>p</i>‐dioxin causes an increase in protein kinases growth hepatic associated with epidermal factor receptor in the plasma membrane Journal of Biochemical Toxicology · 1988 · 60 citations
    7. Ornithine Decarboxylase Expression Leads to Translocation and Activation of Protein Kinase CK2 in Vivo Journal of Biological Chemistry · 1997 · 52 citations
    8. Protein kinase C is a key target for attenuation of Leigh syndrome by rapamycin bioRxiv (Cold Spring Harbor Laboratory) · 2019 · 5 citations
    9. Genetic alteration of cyclic adenosine 3',5'-monophosphate-dependent protein kinase subunit expression affects calcium currents and beta-endorphin release in AtT-20 clonal pituitary cells. Molecular Endocrinology · 1994
    10. Overexpression of protein kinase C-α in the epidermis of transgenic mice results in striking alterations in phorbol ester-induced inflammation and COX-2, MIP-2 and TNF-α expression but not tumor promotion Journal of Cell Science · 1999 · 135 citations
    11. Protein kinase Cepsilon is linked to 12-O-tetradecanoylphorbol-13-acetate-induced tumor necrosis factor-alpha ectodomain shedding and the development of metastatic squamous cell carcinoma in protein kinase Cepsilon transgenic mice. PubMed · 2003 · 79 citations
    12. Topical Application of a Protein Kinase C Inhibitor Reduces Skin and Hair Pigmentation 2004 · 60 citations
    13. Cyclosporin A Promotes Hair Epithelial Cell Proliferation and Modulates Protein Kinase C Expression and Translocation in Hair Epithelial Cells Journal of Investigative Dermatology · 2001 · 45 citations
    14. Protein Kinase C<i>ε</i>, Which Is Linked to Ultraviolet Radiation-Induced Development of Squamous Cell Carcinomas, Stimulates Rapid Turnover of Adult Hair Follicle Stem Cells Journal of skin cancer · 2013 · 10 citations
    15. Foxn1 promotes keratinocyte differentiation by regulating the activity of protein kinase C Differentiation · 2007 · 26 citations
    16. Inhibition of the development of metastatic squamous cell carcinoma in protein kinase C epsilon transgenic mice by alpha-difluoromethylornithine accompanied by marked hair follicle degeneration and hair loss. PubMed · 2003 · 26 citations
    17. A protein kinase target of a PDK1 signalling pathway is involved in root hair growth in Arabidopsis The EMBO Journal · 2004 · 280 citations
    18. Atypical Protein Kinase C Isoform, aPKCλ, Is Essential for Maintaining Hair Follicle Stem Cell Quiescence Journal of Investigative Dermatology · 2015 · 24 citations
    19. Bioinformatic analysis of gene expression data reveals Src family protein tyrosine kinases as key players in androgenetic alopecia Frontiers in Medicine · 2023
    20. Establishment of an Efficient Primary Culture System for Human Hair Follicle Stem Cells Using the Rho-Associated Protein Kinase Inhibitor Y-27632 Frontiers in cell and developmental biology · 2021 · 16 citations
    21. Forsythiaside A Activates AMP-Activated Protein Kinase and Regulates Oxidative Stress via Nrf2 Signaling International Journal of Molecular Sciences · 2023 · 7 citations
    22. The Mixed Lineage Kinase Leucine-Zipper Protein Kinase Exhibits a Differentiation-Associated Localization in Normal Human Skin and Induces Keratinocyte Differentiation upon Overexpression Journal of Investigative Dermatology · 2000 · 17 citations
    23. Salicylate induces epithelial actin reorganization via activation of the AMP-activated protein kinase and promotes wound healing and contraction in mice Scientific Reports · 2024 · 8 citations
    24. Mathematical Modeling and Inference of Epidermal Growth Factor-Induced Mitogen-Activated Protein Kinase Cell Signaling Pathways International Journal of Molecular Sciences · 2024 · 3 citations
    25. Purified Vitexin Compound 1 Inhibits UVA-Induced Cellular Senescence in Human Dermal Fibroblasts by Binding Mitogen-Activated Protein Kinase 1 Frontiers in Cell and Developmental Biology · 2020 · 3 citations
    26. AMP-activated Protein Kinase 활성체인 Metformin의 모발 성장에 미치는 영향 대한피부과학회지 · 2019
    27. Phosphatidic Acid Has a Potential to Promote Hair Growth In Vitro and In Vivo, and Activates Mitogen-Activated Protein Kinase/Extracellular Signal-Regulated Kinase Kinase in Hair Epithelial Cells 2003 · 46 citations
    28. Melatonin regulates the mitogen-activated protein kinase ( MAPK ) pathway via the circMPP5-miR-211-MAPK3 axis to induce secondary hair follicle differentiation and development in newborn Cashmere goat kids Research Square (Research Square) · 2022 · 1 citations
    29. Involvement of Activation of Mitogen-Activated Protein Kinase (MAPK)/Extracellular Signal-Regulated Kinase (ERK) Signaling Pathway in Proliferation of Urethral Plate Fibroblasts in Finasteride-Induced Rat Hypospadias Medical Science Monitor · 2018 · 10 citations
    30. A Ca <sup>2+</sup> /calmodulin-dependent protein kinase required for symbiotic nodule development: Gene identification by transcript-based cloning Proceedings of the National Academy of Sciences · 2004 · 477 citations