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Polycystic Ovary Syndrome (PCOS) is a common condition in women that can cause metabolic, reproductive, and psychological issues, and requires lifestyle changes and medication for management.

A thorough initial check-up is essential before sperm banking to ensure the best chance of preserving good quality sperm.

Cross-sex hormone therapy is important for managing gender dysphoria and requires careful monitoring and healthcare provider education.

Finasteride improves heart function and repairs damage after heart attack in mice.

Finasteride reduces corpus cavernosum weight but doesn't affect erectile response in rats.

Higher testosterone levels can increase the risk of certain diseases like type 2 diabetes in women and prostate cancer in men, but can also protect against autoimmune diseases and hair loss. It also affects body fat and bone density.

Increased free testosterone can lead to stronger bones and less body fat but also higher risks of prostate cancer, hair loss, spine issues, and high blood pressure.

Medications for PCOS don't seem to raise heart disease risk.

Hormone therapy for transgender females increases the risk of blood clots and requires careful dosing, monitoring, and lifelong management.

Solidified SEDDS improve drug stability and bioavailability better than liquid SEDDS.

Certain drugs, especially antiandrogens and spironolactone, significantly increase the risk of gynecomastia.

HNG may help prevent the negative effects of chemotherapy on sperm production and white blood cell counts.

New treatments for low male hormones improved sexual function and mood but had unclear risks, especially for older men.

High doses of fluconazole can cause reversible hair loss.

Finasteride for hair loss increases risk of long-lasting sexual dysfunction.

The guideline recommends mental health involvement in diagnosing gender identity disorder and outlines hormone and surgical treatment protocols, emphasizing safety, informed consent, and long-term monitoring.

The guideline provides healthcare professionals in South Africa with instructions for comprehensive, multidisciplinary gender-affirming care, including HIV prevention and treatment for transgender and gender diverse individuals.

Advancements in male reproductive medicine are ongoing, but more research and improved treatments are needed in several areas.

Testing for CAG repeat polymorphism in the androgen receptor gene is not currently recommended for managing hypogonadism.

Male hormones worsen kidney transplant damage, but blocking them helps.

Heparin and protamine are promising in tissue repair and organ regeneration, including skin and hair.

The conclusion is that while oral contraceptive pills are effective for PCOS-related high androgen levels, new treatments with fewer side effects are needed.

The research found that PCOS has common genetic factors regardless of how it is diagnosed and is linked to metabolic and reproductive issues.

PRP treatment improves hair density and diameter in women with androgenetic alopecia.

No cure for female pattern hair loss, but various effective treatments exist.

The document concludes that non-operative treatment for gender dysphoria is safe and effective, and hormone therapy does not increase cancer risk.

Testosterone supplements can increase muscle mass and strength in older men with low levels, but long-term effects and risks need more research.

Long-term testosterone therapy can cause hormone suppression, affect prostate and heart health, and alter physical characteristics, but does not increase prostate cancer risk and needs more research for full risk assessment.

The document concludes that managing hirsutism involves identifying the cause, using a scoring system for severity, combining cosmetic and medical treatments, encouraging weight loss, and providing psychological support, while noting the need for more research on drug treatments.

Testosterone replacement therapy improves libido, mood, muscle strength, and bone density in men with Testosterone Deficiency Syndrome.