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Metformin helps with menstrual cycles and insulin levels in PCOS but is less effective for hair growth, diabetes prevention, and weight loss, and may improve fertility and reduce diabetes risk.

The Rotterdam Study found risk factors for elderly diseases, links between lifestyle and genetics with health conditions, and aimed to explore new areas like DNA methylation and sensory input effects on brain function.

The document concludes that the understanding of scar formation is incomplete and current prevention and treatment for hypertrophic scars and keloids are not fully effective.

Some drugs can cause rare but potentially deadly skin reactions, and early treatment and avoiding the drug again are key.

The report recommends personalized treatment for women's sexual dysfunctions and more research on effective therapies.

Androgen deprivation therapy for prostate cancer can cause sexual, physical, and psychological side effects, and doctors should manage these carefully.

Insulin resistance and obesity are key factors in the development and worsening of polycystic ovary syndrome, and lifestyle changes are important for managing it.

About 7% to 15% of Iranian women have polycystic ovary syndrome, depending on the criteria used to diagnose it.

The guidelines suggest a detailed approach to diagnosing and treating lupus, with a focus on regular check-ups, personalized medicine, and a range of drug options for different cases.

Different types of skin cells play specific roles in development, healing, and cancer.

Pregnancy can cause various skin changes and diseases, with PUPPP being the most common skin condition specific to pregnancy.

Artificial skin development has challenges, but new materials and understanding cell behavior could improve tissue repair. Also, certain growth factors and hydrogel technology show promise for advanced skin replacement therapies.

Metformin helps manage polycystic ovary syndrome by improving insulin resistance and ovulation, but more research is needed on its full effects.

The PDGF/PDGFR pathway is a potential drug target with mixed success in treating various diseases, including some cancers and fibrosis.

DrugNet effectively identifies new uses for existing drugs and may save resources in drug development.

Early diagnosis and individualized treatment improve outcomes for Congenital Adrenal Hyperplasia.

Estrogen therapy can reduce skin aging but has cancer risks.

Young adults have about 230,000 tactile nerve fibers, decreasing 5-8% per decade with age.

Estrogen loss during menopause worsens skin health, but hormone replacement therapy may improve it, though more research is needed.

Fat-derived stem cells show promise for skin repair and reducing aging signs but need more research for consistent results.

TRP channels in the skin are important for sensation and health, and targeting them could help treat skin disorders.

The telogen phase of hair growth is active and important for preparing hair follicles for regeneration, not just a resting stage.

Potassium channel openers could help treat cardiovascular diseases and asthma but require better targeting to specific tissues for effective use.

Children with atopic dermatitis often have sleep problems, affecting their growth and behavior.

More men are getting benign prostatic hyperplasia, and there are many treatments, from medication to surgery, with new methods being developed.

Drug advertising has greatly increased, changing consumer behavior and raising concerns about its influence on healthcare and patient protection.

New single-cell analysis techniques are improving our understanding of stem cells and could help in treating diseases.

DHT may increase the risk of heart disease and death in elderly men.

The document concludes that early diagnosis and treatment of Congenital Adrenal Hyperplasia are crucial for preventing serious health issues and improving patient outcomes.

To diagnose hair loss, use a systematic approach including history, exams, and tests.