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The guideline recommends mental health involvement in diagnosing gender identity disorder and outlines hormone and surgical treatment protocols, emphasizing safety, informed consent, and long-term monitoring.

Hair follicles are complex, dynamic mini-organs that help us understand cell growth, death, migration, and differentiation, as well as tissue regeneration and tumor biology.

Chemotherapy in the first trimester of pregnancy is risky, but in the second and third trimesters, it's generally safe with careful drug selection and timing.

Male hormones may play a role in the development of heart disease, and more research is needed to understand their effects.

Hair follicle development is controlled by interactions between skin tissues and specific molecular signals.

The hypothesis suggests that PCOS may start early in life due to genetic and environmental factors, influencing future reproductive and metabolic problems.

The paper concludes that understanding melanocyte development can help in insights into skin diseases and melanoma diversity.

Metformin helps with menstrual cycles and insulin levels in PCOS but is less effective for hair growth, diabetes prevention, and weight loss, and may improve fertility and reduce diabetes risk.

Certain proteins, Lgr5 and Lgr6, are important markers of adult stem cells and are involved in tissue repair and cancer development.

Chemicals and body size might change when puberty starts and progresses, but more research is needed to confirm this.

Insulin resistance is a key factor in polycystic ovary syndrome, but genetics may also contribute.

The timing of when the gene Bmal1 is active affects aging and survival, with its absence during development, not adulthood, leading to premature aging.

PCOS is caused by both genetics and environmental factors like diet and obesity.

Visible light can damage skin and most sunscreens don't block it well; more research is needed on its effects and protection methods.

The hedgehog signaling pathway is crucial for hair growth but not for the initial creation of hair follicles.

Hair follicle development and microbes help regulatory T cells gather in newborn skin.

Estrogens can improve skin aging but carry risks; more research is needed on safer treatments.

Early development of hair, teeth, and glands involves specific signaling pathways and cellular interactions.

Some skin medications are safe during pregnancy and breastfeeding, but others can harm the baby and should be avoided.

Zinc is crucial for growth and health in rats.

AGA more common in men, Koreans have lower rates and unique patterns.

Keratinocytes help heal skin wounds by interacting with immune cells and producing substances that kill pathogens.

The document concludes that accurate diagnosis of ichthyosis is crucial for treatment and genetic advice, and ongoing research is needed for better therapies.

The WNT signaling pathway is important in many diseases and targeting it could offer new treatments.

Matriptase is crucial for keeping epithelial tissues healthy and functioning properly.

Gene therapy with the Math1 gene helped regenerate balance-related cells and improve balance in mice.

The document concludes that understanding hair structure is key to diagnosing hair abnormalities and recommends gentle hair care for management.

The BASP classification is a detailed and accurate way to categorize hair loss in both men and women.

Polycystic Ovary Syndrome likely starts in childhood and may be genetic and influenced by early hormone exposure.

Finasteride exposure in pregnancy causes genital abnormalities in male rats.