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The timing of when the gene Bmal1 is active affects aging and survival, with its absence during development, not adulthood, leading to premature aging.

Oral retinoids can cause side effects ranging from mild to severe, including birth defects, and require careful monitoring and contraception.

The document suggests that clinical trials for PCOS should focus on meaningful primary outcomes like live birth rates, rather than less reliable surrogate markers.

Premature aging increases the risk of immune problems and autoimmune diseases.

Congenital Adrenal Hyperplasia is a genetic disorder with two forms, causing symptoms like early puberty and severe acne, but can be identified through screening and treated with glucocorticoids.

Nonclassic adrenal hyperplasia is a genetic condition that can cause early puberty and fertility problems, treated with specific steroids.

A new mutation in the LIPH gene was found to cause a rare hair disorder in a Japanese boy.

Ovulation disorders are a major cause of infertility and menstrual problems in women.

Nonclassic congenital adrenal hyperplasia is a common genetic disorder that can cause a range of symptoms and requires personalized treatment.

Some vitamins and minerals like vitamin D and iron can help with certain types of hair loss, but more research is needed for others.

Loose Anagen Hair Syndrome is a hereditary condition causing hair loss in children due to abnormal hair follicles.

Antidepressants, 5α-reductase inhibitors, and isotretinoin can cause long-lasting sexual dysfunction.

Family members of North Indian women with PCOS have a high rate of metabolic syndrome.

Certain proteins and their receptors are more active during the growth phase of human hair and could be targeted to treat hair disorders.

CAH is a genetic disorder affecting cortisol production and causing hormonal imbalances, with treatment and diagnosis varying by form and symptoms.

SV40 T antigen in hair follicles causes abnormal hair and health issues in mice.

The document concludes that managing health issues like menopause, cardiovascular risk, and hair loss is crucial for promoting longevity in aging women.

Finasteride and dutasteride are effective in treating male hair loss but can cause sexual side effects and birth defects.

Cats with abnormal hair had DSG4 gene changes causing hair problems.

The document concludes that managing PCOS involves lifestyle changes, medication, and monitoring for associated health risks.

Experts agree that PCOS affects women's health in complex ways, but more research is needed to understand and treat it effectively.

Metformin helps with menstrual cycles and insulin levels in PCOS but is less effective for hair growth, diabetes prevention, and weight loss, and may improve fertility and reduce diabetes risk.

Female guinea pigs exposed to less allopregnanolone before birth showed more anxiety-like behavior.

Age, gender, and hair loss affect scalp characteristics differently in young Caucasian adults.

Faulty LEF1 activation causes faster skin cell differentiation in premature aging syndrome.

The document suggests treating individuals with nonclassic congenital adrenal hyperplasia who show symptoms, especially those related to excess male hormones.

Mutations in the KRT85 gene cause hair and nail problems.

Fibrodysplasia ossificans progressiva is a rare genetic disorder that causes extra bone growth and symptoms of premature aging.

A newborn with congenital syphilis had unusual hair loss possibly caused by the infection.

A patient with Werner syndrome showed a range of aging-like symptoms and metabolic issues, underscoring the need for early detection and treatment.